ArticleJournal of oral and maxillofacial pathology : JOMFP2012
Pathophysiology of Langerhans cells.
Article in Journal of oral and maxillofacial pathology : JOMFP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Small Fiber Neuropathy in Burning Mouth Syndrome: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Zoonotic and Anthropophilic Trichophyton mentagrophytes Complex Infection in Human: An Update and Narrative Review.Mycoses · 2025Review
- Polyostotic Langerhans cell histiocytosis presenting as halitosis in a 24-year-old man: a case report.Journal of medical case reports · 2025Article
- Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.International journal of extreme manufacturing · 2025Review
- Immune checkpoint inhibitors in melanoma: mechanisms, immune cell interactions, and the tumour microenvironment.Frontiers in immunology · 2025Review
- Incorporating immune cell surrogates into a full-thickness tissue equivalent of human skin to characterize dendritic cell activation.Scientific reports · 2024Article
- Regulatory T cells in skin regeneration and wound healing.Military Medical Research · 2023Review
- Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types.Frontiers in immunology · 2023Article
- Enhancement strategies for transdermal drug delivery systems: current trends and applications.Drug delivery and translational research · 2022Article
- SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection.Glycoconjugate journal · 2021Review
- Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options.Clinical and experimental medicine · 2021Review
- Incidental Diagnosis on Orthopantomography of Langerhans Cell Histiocytosis with Multifocal Jaw Involvement: A Case Report of Single-System Disease.The American journal of case reports · 2020Article
- Langerhans Cell Histiocytosis of the Temporal Bone.Ochsner journal · 2020Article
- Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease.Journal of immunotoxicology · 2019Review
- Microbiota and Immune-Mediated Skin Diseases-An Overview.Microorganisms · 2019Review
- Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region.Scientific reports · 2018Article
- Vaginal Lactobacilli Induce Differentiation of Monocytic Precursors Toward Langerhans-like Cells:Frontiers in immunology · 2018Article
- Regional differences in the density of Langerhans cells, CD8-positive T lymphocytes and CD68-positive macrophages: a preliminary study using elderly donated cadavers.Anatomy & cell biology · 2015Article
- A Comparative Immunohistochemical Analysis of Langerhans Cells in Oral Mucosa, Oral Lichen Planus and Oral Squamous Cell Carcinoma.Journal of clinical and diagnostic research : JCDR · 2015Article
- Langerhans Cell Expression in Oral Submucous Fibrosis: An Immunohistochemical Analysis.Journal of clinical and diagnostic research : JCDR · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerhans cells (LCs) were first described by Paul Langerhans, in 1868, as dendritically shaped cells, which were located in the squamous epithelia of epidermis. Later on, these cells were identified in all stratified squamous epithelium of mammals. Dendritic cells (DCs) play an important role in local defense mechanisms in the epithelium. LCs are situated usually in the suprabasal layer of stratified squamous epithelia of oral mucosa and epidermis of skin. They constitute 3% of the cell population in epidermis. LCs are thought to act as antigen presenting cells (APCs) during initiation of immune responses. With the help of APCs, the lymphocytes are able to recognize and respond to specific microbes. In this paper we have reviewed the origin, distribution, demonstration and mechanism of action of LCs and their role in different pathological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.