ArticleTetrahedron2012
Synthesis of Tetrazolo-Fused Benzodiazepines and Benzodiazepinones by a Two-Step Protocol Using an Ugi-Azide Reaction for Initial Diversity Generation.
Article in Tetrahedron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Formaldehyde surrogates in multicomponent reactions.Beilstein journal of organic chemistry · 2025Review
- Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators.Journal of medicinal chemistry · 2024Article
- Microwave-Assisted Post-Ugi Reactions for the Synthesis of Polycycles.Molecules (Basel, Switzerland) · 2022Review
- Synthesis of N-heterocycles containing 1,5-disubstituted-1H-tetrazole via post-Ugi-azide reaction.Molecular diversity · 2020Review
- Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model.ACS chemical neuroscience · 2019Article
- Tetrazoles via Multicomponent Reactions.Chemical reviews · 2019Review
- One-pot synthesis of novel 1-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives via an Ugi-azide 4CR process.Molecular diversity · 2018Article
- Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations.ACS combinatorial science · 2017Article
- α-Amino Acid-Isosteric α-Amino Tetrazoles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Novel succinct routes to Quinoxalines and 2-Benzimidazolylquinoxalines via the Ugi reaction.Tetrahedron letters · 2014Article
- MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines.Tetrahedron · 2014Article
- Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.Beilstein journal of organic chemistry · 2014Review
- Various cyclization scaffolds by a truly Ugi 4-CR.Organic & biomolecular chemistry · 2013Article
- Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry.Organic letters · 2013Article
- A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families.Tetrahedron letters · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A two-step strategy for the synthesis of arrays of tricyclic tetrazolo-fused benzodiazepines and benzodiazepinones has been investigated. The protocol uses ortho-N-Boc phenylisocyanides and phenylglyoxaldehydes or ethyl glyoxylate in the 4-component Ugi-Azide reaction to afford MCR (Multi Component Reactions) derived adducts equipped with the desired diversity inputs. A subsequent acidic treatment (TFA/DCE) allows a simultaneous deprotection-cyclization leading to the final products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.