ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Unraveling the complexity of vascular tone regulation: a multiscale computational approach to integrating chemo-mechano-biological pathways with cardiovascular biomechanics.Biomechanics and modeling in mechanobiology · 2024Article
- A model of anemic tissue perfusion after blood transfusion shows critical role of endothelial response to shear stress stimuli.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Influence of dual-specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles.Physiological reports · 2020Article
- Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications.European heart journal · 2019Article
- Blood Rheology: Key Parameters, Impact on Blood Flow, Role in Sickle Cell Disease and Effects of Exercise.Frontiers in physiology · 2019Review
- Optimal hematocrit in an artificial microvascular network.Transfusion · 2017Article
- Epoetin beta pegol ameliorates flow-mediated dilation with improving endothelial nitric oxide synthase coupling state in nonobese diabetic rats.Cardiovascular therapeutics · 2017Article
- Shear-Induced Nitric Oxide Production by Endothelial Cells.Biophysical journal · 2016Article
- The Effect of Red Blood Cell Transfusion on Cerebral Autoregulation in Patients with Severe Traumatic Brain Injury.Neurocritical care · 2015Observational
- Non-Newtonian flow of blood in arterioles: consequences for wall shear stress measurements.Microcirculation (New York, N.Y. : 1994) · 2014Article
- Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women.Vascular health and risk management · 2014Article
- Two-phase model for prediction of cell-free layer width in blood flow.Microvascular research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Here, we present an analytic model of arteriolar mechanics that accounts for key autoregulation mechanisms, including the myogenic response and the vasodilatory effects of nitric oxide (NO) in the vasculature. It couples the fluid mechanics of blood flow in arterioles with solid mechanics of the vessel wall and includes the effects of wall shear stress- and stretch-induced endothelial NO production. The model can be used to describe the regulation of blood flow and NO transport under small changes in hematocrit and to analyze the regulatory response of arterioles to small changes in hematocrit. Our analysis revealed that the experimentally observed paradoxical increase in cardiac output with small increases in hematocrit results from the combination of increased NO production and the effects of a strong myogenic response modulated by elevated levels of WSS. Our findings support the hypothesis that vascular resistance varies inversely with blood viscosity for small changes in hematocrit in a healthy circulation that responds to shear stress stimuli. They also suggest beneficial effects independent of changes in O(2) carrying capacity associated with the postsurgical transfusion of one or two units of blood.
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