ArticleMolecular biology and evolution2013
Evolution of flux control in the glucosinolate pathway in Arabidopsis thaliana.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Integrating Metabolic and Gene Expression Profiling of Glucosinolate Biosynthesis Under Drought Stress inInternational journal of molecular sciences · 2026Article
- Evolutionary Systems Biology Identifies Genetic Trade-offs in Rice Defense against Aboveground and Belowground Attackers.Plant & cell physiology · 2025Article
- How does plant chemodiversity evolve? Testing five hypotheses in one population genetic model.The New phytologist · 2025Article
- Soil variation among natural habitats alters glucosinolate content in a wild perennial mustard.Journal of experimental botany · 2023Article
- Further insight into decreases in seed glucosinolate content based on QTL mapping and RNA-seq in Brassica napus L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Genome-wide association mapping within a localPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Transcription Factors Evolve Faster Than Their Structural Gene Targets in the Flavonoid Pigment Pathway.Molecular biology and evolution · 2022Article
- A multiscale approach to detect selection in nonmodel tree species: Widespread adaptation despite population decline inEvolutionary applications · 2020Article
- The evolution of metabolism: How to test evolutionary hypotheses at the genomic level.Computational and structural biotechnology journal · 2020Review
- Hierarchical and Dynamic Regulation of Defense-Responsive Specialized Metabolism by WRKY and MYB Transcription Factors.Frontiers in plant science · 2019Article
- Article
- Metabolic Determinants of Enzyme Evolution in a Genome-Scale Bacterial Metabolic Network.Genome biology and evolution · 2018Article
- Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution.Molecular biology and evolution · 2018Article
- The effects of repeated whole genome duplication events on the evolution of cytokinin signaling pathway.BMC evolutionary biology · 2018Article
- Plasticity of plant defense and its evolutionary implications in wild populations of Boechera stricta.Evolution; international journal of organic evolution · 2018Article
- Characterizing the roles of changing population size and selection on the evolution of flux control in metabolic pathways.BMC evolutionary biology · 2017Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Transcriptional Analysis of serk1 and serk3 Coreceptor Mutants.Plant physiology · 2016Article
- Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable.Biology direct · 2016Article
- Evolution of a Catalytic Mechanism.Molecular biology and evolution · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Network characteristics of biochemical pathways are believed to influence the rate of evolutionary change in constituent enzymes. One characteristic that may affect rate heterogeneity is control of the amount of product produced by a biochemical pathway or flux control. In particular, theoretical analyses suggest that adaptive substitutions should be concentrated in the enzyme(s) that exert the greatest control over flux. Although a handful of studies have found a correlation between position in a pathway and evolutionary rate, these investigations have not examined the relationship between evolutionary rate and flux control. Given that genes with greater control will experience stronger selection and that the probability of fixation is proportional to the selective advantage, we ask the following: 1) do upstream enzymes have majority flux control, 2) do enzymes with majority flux control accumulate adaptive substitutions, and 3) are upstream enzymes under higher selective constraint? First, by perturbing the enzymes in the aliphatic glucosinolate pathway in Arabidopsis thaliana with gene insertion lines, we show that flux control is focused in the first enzyme in the pathway. Next, by analyzing several sequence signatures of selection, we also show that this enzyme is the only one in the pathway that shows convincing evidence of selection. Our results support the hypothesis that natural selection preferentially acts on enzymes with high flux control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.