ArticlePediatric nephrology (Berlin, Germany)2013
Renal function and injury in infants and young children with congenital heart disease.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.Nature biomedical engineering · 2026Article
- Acute Kidney Injury Predictors and Outcomes after Cardiac Surgery in Children with Congenital Heart Disease: An Observational Cohort Study.Diagnostics (Basel, Switzerland) · 2022Article
- Chronic kidney disease in patients with congenital heart disease: a nationwide, register-based cohort study.European heart journal open · 2022Article
- Perioperative albuminuria and clinical model to predict acute kidney injury in paediatric cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2022Observational
- The use of diagnostic tools for pediatric AKI: applying the current evidence to the bedside.Pediatric nephrology (Berlin, Germany) · 2021Review
- Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys.Frontiers in physiology · 2021Article
- Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury.Congenital heart disease · 2019Article
- Altered in utero kidney development in newborns with congenital heart disease.Pediatric research · 2019Article
- Prevalence and associated factors of renal dysfunction and proteinuria in cyanotic congenital heart disease.Pediatric nephrology (Berlin, Germany) · 2018Article
- PROGRESSION OF CHRONIC KIDNEY DISEASE AFTER ACUTE KIDNEY INJURY.Progress in pediatric cardiology · 2016Article
- Effects of acute kidney injury and chronic hypoxemia on fibroblast growth factor 23 levels in pediatric cardiac surgery patients.Pediatric nephrology (Berlin, Germany) · 2016Article
- Chronic kidney disease in congenital heart disease patients: a narrative review of evidence.Canadian journal of kidney health and disease · 2015Review
- Prevalence and predictors of decreased glomerular filtration rate in tibetan children with congenital heart disease.Indian journal of pediatrics · 2014Article
- Renal function in children with cyanotic congenital heart disease: pre- and post-cardiac surgery evaluation.Iranian journal of pediatrics · 2014Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate renal function and injury in infants and young children with congenital heart disease (CHD).
methodsWe prospectively enrolled 58 CHD children aged ≤3 years and 20 age-matched controls and divided these into four groups: Group I, acyanotic CHD (n = 24); Group II, cyanotic CHD with arterial oxygen saturation of >75 % (n = 20); Group III, cyanotic CHD with arterial oxygen saturation of ≤75 % (n = 14); Group IV, normal controls (n = 20). Urinary levels of microalbumin (MA), N-acetyl-ß-D-glucosaminidase (NAG), and α1-microglobulin (α1-MG) corrected by creatinine (UCr) were compared.
resultsChildren with CHD had elevated urinary α1-MG/UCr levels, with Group III children having the highest level. Groups I and III children had higher urinary NAG/UCr levels than those of Groups II and IV. Urinary MA/UCr levels in the three patient groups were comparable and significantly higher than that in the control group. A α1-MG × 100/ (α1-MG + MA) of <15 %, indicative of glomerular damage, was present in two patients in Group I and one in Group III, but none in Group II.
conclusionsTubular injury can occur in CHD patients during infancy and early childhood. Among our patient cohort, it was most prominent in children with severe cyanosis. Glomerular injury was detected in some individuals with advanced heart failure or severe cyanosis.
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