ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2013
Neuroinflammation, neuroautoimmunity, and the co-morbidities of complex regional pain syndrome.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Amputation for Complex Regional Pain Syndrome: Meta-Analysis and Validation of a Histopathology Scoring System.Pain medicine (Malden, Mass.) · 2023Pooled it
- Intranasal iron administration induces iron deposition, immunoactivation, and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice.Zoological research · 2025Article
- Article
- Imbalance in positive and negative acceleration ratio of alpha oscillation in patients with complex regional pain syndrome.Heliyon · 2024Article
- Impaired Pain Processing at a Brainstem Level Is Involved in Maladaptive Neuroplasticity in Patients with Chronic Complex Regional Pain Syndrome.International journal of molecular sciences · 2022Article
- The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure.Frontiers in cellular neuroscience · 2022Article
- Article
- Peripheral neuroimmune interactions: selected review and some clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- Subliminal (latent) processing of pain and its evolution to conscious awareness.Neuroscience and biobehavioral reviews · 2018Review
- [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study.Medicine · 2017Article
- Acute versus chronic phase mechanisms in a rat model of CRPS.Journal of neuroinflammation · 2016Article
- Environmental Toxicants-Induced Immune Responses in the Olfactory Mucosa.Frontiers in immunology · 2016Review
- Neurocognitive and Neuroplastic Mechanisms of Novel Clinical Signs in CRPS.Frontiers in human neuroscience · 2016Review
- Myalgic Encephalomyelitis: Symptoms and Biomarkers.Current neuropharmacology · 2015Review
- Article
- Acute and chronic phases of complex regional pain syndrome in mice are accompanied by distinct transcriptional changes in the spinal cord.Molecular pain · 2013Article
- Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Making connections: using telehealth to improve the diagnosis and treatment of Complex Regional Pain Syndrome, an underrecognized neuroinflammatory disorder.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Imaging biomarkers and the role of neuroinflammation in neuropathic pain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex Regional Pain Syndrome (CRPS) is associated with non-dermatomal patterns of pain, unusual movement disorders, and somatovisceral dysfunctions. These symptoms are viewed by some neurologists and psychiatrists as being psychogenic in origin. Recent evidence, however, suggests that an autoimmune attack on self-antigens found in the peripheral and central nervous system may underlie a number of CRPS symptoms. From both animal and human studies, evidence is accumulating that neuroinflammation can spread, either anterograde or retrograde, via axonal projections in the CNS, thereby establishing neuroinflammatory tracks and secondary neuroinflammatory foci within the neuraxis. These findings suggest that neuroinflammatory lesions, as well as their associated functional consequences, should be evaluated during the differential diagnosis of non-dermatomal pain presentations, atypical movement disorders, as well as other "medically unexplained symptoms", which are often attributed to psychogenic illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.