ArticlePathology oncology research : POR2013
Could spindle cell lung carcinoma be considered and treated as sarcoma, according to its clinical course, morphology, immunophenotype and genetic finding?
Article in Pathology oncology research : POR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma: a population-based retrospective study using SEER data.Translational cancer research · 2026Article
- A Rare Tumor in a Septuagenarian Female 16 Years After Radical Mastectomy for Breast Carcinoma.Clinical case reports · 2025Article
- Development and validation of a prognostic predictive model of pulmonary spindle cell carcinoma from the surveillance, epidemiology and end results database.Translational cancer research · 2022Article
- Pulmonary spindle cell carcinoma with hemothorax: A rare case report.International journal of surgery case reports · 2022Article
- Pulmonary spindle cell carcinoma with unusual morphology: A rare case report and review of the literature.Medicine · 2017Review
- An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage.The American journal of case reports · 2015Article
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Authors and funding
6 authors.
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Abstract
The actual nature of spindle cell carcinoma has been debated extensively because of its rarity. It carries a poor prognosis, even when early-stage disease is diagnosed and resected. In view of the rarity and the significance of the histological diagnosis, we report a patient with rapidly progressing spindle cell lung carcinoma with soft tissue metastasis. Diagnosis was confirmed by immunohistochemistry finding. Analysis of the TP53 gene mutations by polymerase chain reaction and DNA sequencing revealed insertion of single thymine resulting in frameshift mutation in the exon 8. Prognosis of spindle cell lung carcinoma might be determined by the sarcoma component of the tumor and, based on that, we wonder if this type of lung carcinoma could be followed-up and treated by strategies for soft tissue sarcomas, because of its rapid, sarcomatous type of growth, beside the properly lung carcinoma oncological treatment.
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