ArticleGenetica2012
Testing for associations between candidate genes for circadian rhythms and individual variation in sleep behaviour in blue tits.
Article in Genetica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- The myth of the metabolic baseline: sleep-wake cycles undermine a foundational assumption in organismal biology.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Female chronotype relates to lay date but not fitness in an island population of great tits.Oecologia · 2026Article
- Birds of a feather flock together: a dataset for Clock and Adcyap1 genes from migration genetics studies.Scientific data · 2023Article
- Intrinsic individual variation in daily activity onset and plastic responses on temporal but not spatial scales in female great tits.Scientific reports · 2022Article
- Diurnal and Nocturnal Behaviour of Cheetahs (Animals : an open access journal from MDPI · 2022Article
- Sleep research goes wild: new methods and approaches to investigate the ecology, evolution and functions of sleep.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Repeatability of circadian behavioural variation revealed in free-ranging marine fish.Royal Society open science · 2017Article
- Genetic Correlates of Individual Differences in Sleep Behavior of Free-Living Great Tits (Parus major).G3 (Bethesda, Md.) · 2016Article
- Avian circadian organization: a chorus of clocks.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of sleep in animals is controlled by environmental factors, homeostatic mechanisms and endogenous circadian oscillators. The molecular mechanisms underlying such circadian oscillators have been described in detail and a variety of genes that are components of these molecular clocks have been reported. In addition to inter-specific variation in the temporal organization of sleep, there is significant intra-specific variation in different organisms. From numerous studies in humans it is known that polymorphisms in the regulatory clock genes are causing such variation but knowledge about associations between naturally occurring polymorphisms and sleep patterns in wild animals is scarce. In this study, we investigated the phenotypic sleep correlates of eleven previously described polymorphisms in seven candidate genes within a free-living blue tit Cyanistes caeruleus population. We detected associations between four single nucleotide polymorphisms and three of the nine tested sleep parameters representing temporal organization. Awakening time was associated with polymorphisms in AANAT and PERIOD2, morning latency with a polymorphism in CKIε and the duration of the longest sleep bout with a second polymorphism in AANAT. However, by a permutation procedure we showed that the number of significant results and the most significant association has a study-wide likelihood of 46.7 and 5.9 % respectively. Further replication studies are needed to evaluate the potential associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.