SynthesisNature genetics2012
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 11 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 11 pooled it
17.1field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
97 citing papers in PubMed, 11 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.Nature communications · 2025Pooled it
- Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.Investigative ophthalmology & visual science · 2024Pooled it
- Pooled it
- Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.Cell reports. Medicine · 2024Pooled it
- Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank.PloS one · 2022Pooled it
- Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.Nature genetics · 2018Pooled it
- Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.Nature genetics · 2016Pooled it
- Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma.PloS one · 2016Pooled it
- Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.American journal of human genetics · 2013Pooled it
- Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis.PloS one · 2013Pooled it
- Association of genetic variants with primary angle closure glaucoma in two different populations.PloS one · 2013Pooled it
- TNFα-dependent modulation of WT1-MMP9 regulatory axis links developmental and inflammatory pathways in glaucoma.iScience · 2026Article
- Risk-Stratified Interventional Management and Surgical Decision-Making in Primary Glaucoma.Biomedicines · 2026Review
- A Human Pharmacogenomics Approach Provides Insight Into the Pathogenesis and Pathophysiology of Steroid-Induced Ocular Hypertension.Ophthalmology science · 2026Article
- Visual field progression in varying severities of treated patients with primary angle closure glaucoma.Scientific reports · 2026Article
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
- Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression.Clinical & experimental ophthalmology · 2025Article
- FOXP4 Variants Are Associated With Plateau Iris and Angle Closure Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Single-Nucleotide Polymorphisms in the Thioredoxin Antioxidant System and Their Association with Diabetic Nephropathy in Slovenian Patients with Type 2 Diabetes-A Preliminary Study.International journal of molecular sciences · 2025Article
- Genetic association of single nucleotide polymorphisms in PLEKHA7 gene with primary angle closure glaucoma (PACG) in a Central-Eastern Punjab cohort of Pakistan.Molecular biology reports · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
79 authors at 20 institutions in 9 countries.
Eranga N Vithana *Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Chiea-Chuen Khor *Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Chunyan Qiao *Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Monisha E NongpiurSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Ronnie GeorgeVision Research Foundation, Sankara Nethralaya, Chennai, India.
Li-Jia ChenDepartment of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Tan DoVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Khaled Abu-AmeroDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Chor Kai HuangShantou University-Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou, China.
Sancy LowNational Institute for Health Research (NIHR) Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London (UCL) Institute of Ophthalmology, London, UK.
Liza-Sharmini A TajudinDepartment of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Shamira A PereraSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Liang XuBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Hongyan JiaBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ching-Lin HoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Kar Seng SimHuman Genetics, Genome Institute of Singapore, Singapore.
Ren-Yi WuSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Clement C Y ThamDepartment of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Paul T K ChewDepartment of Ophthalmology, National University Health System & National University of Singapore, Singapore.
Daniel H SuSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Francis T OenSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Sripriya SarangapaniVision Research Foundation, Sankara Nethralaya, Chennai, India.
Nagaswamy SoumittraVision Research Foundation, Sankara Nethralaya, Chennai, India.
Essam A OsmanDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Hon-Tym WongDepartment of Ophthalmology, Tan Tock Seng Hospital, Singapore.
Guangxian TangXingtai Eye Hospital, Xingtai, China.
Sujie FanHandan Eye Hospital, Handan, China.
Hailin MengAnyang Eye Hospital, Anyang, China.
Dao T L HuongVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Hua WangBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Bo FengBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Mani BaskaranSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Balekudaru ShanthaVision Research Foundation, Sankara Nethralaya, Chennai, India.
Vedam L RamprasadVision Research Foundation, Sankara Nethralaya, Chennai, India.
Govindasamy KumaramanickavelVision Research Foundation, Sankara Nethralaya, Chennai, India.
Sudha K IyengarDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
Alicia C HowSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Kelvin Y LeeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Theru A SivakumaranDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
Victor H K YongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Serena M L TingSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Yang LiDepartment of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Ya-Xing WangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Wan-Ting TaySingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Xueling SimCentre for Molecular Epidemiology, National University of Singapore, Singapore.
Raghavan LavanyaSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Belinda K CornesSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Ying-Feng ZhengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Tina T WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Seng-Chee LoonDepartment of Ophthalmology, National University Health System & National University of Singapore, Singapore.
Vernon K Y YongDepartment of Ophthalmology, Tan Tock Seng Hospital, Singapore.
Naushin WaseemNational Institute for Health Research (NIHR) Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London (UCL) Institute of Ophthalmology, London, UK.
Azhany YaakubDepartment of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Kee-Seng ChiaSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
R Rand AllinghamDepartment of Opthamology, Duke University Medical Center, Durham, North Carolina, USA.
Michael A HauserDepartment of Opthamology, Duke University Medical Center, Durham, North Carolina, USA.
Dennis S C LamDepartment of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Martin L HibberdInfectious Diseases, Genome Institute of Singapore, Singapore.
Shomi S BhattacharyaNational Institute for Health Research (NIHR) Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London (UCL) Institute of Ophthalmology, London, UK.
Mingzhi ZhangShantou University-Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou, China.
Yik Ying TeoHuman Genetics, Genome Institute of Singapore, Singapore.
Donald T TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Jost B JonasDepartment of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Seang-Mei SawSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Do Nhu HonVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Saleh A Al-ObeidanDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Jianjun LiuHuman Genetics, Genome Institute of Singapore, Singapore.
Tran Nguyen Bich ChauOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Cameron P SimmonsOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Jin-Xin BeiState Key Laboratory of Oncology in Southern China, Guangzhou, China.
Yi-Xin ZengState Key Laboratory of Oncology in Southern China, Guangzhou, China.
Paul J FosterNational Institute for Health Research (NIHR) Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London (UCL) Institute of Ophthalmology, London, UK.
Lingam VijayaVision Research Foundation, Sankara Nethralaya, Chennai, India.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Chi-Pui PangDepartment of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.
Ningli Wang *Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Tin Aung *Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
National University of Singapore · SGSingapore Eye Research Institute · SGSingapore National Eye Center · SGSankara Nethralaya · INChinese University of Hong Kong · CNBeijing Tongren Hospital · CNCapital Medical University · CNGenome Institute of Singapore · SGHospital Universiti Sains Malaysia · MYCase Western Reserve University · USDuke Medical Center · USKing Saud University · SANational Hospital of Pediatrics · VNNational Institute for Health Research · GBNational University Health System · SGOxford University Clinical Research Unit · VNTan Tock Seng Hospital · SGAnyang Eye Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHan Dan City Eye Hospital - The Third Hospital of Handan · CN
Funding
Wellcome Trust 084368
Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyCarrier ProteinsCase-Control StudiesCollagen Type XIGenetic LociGlaucoma, Angle-ClosureHumansLogistic ModelsPolymorphism, Single NucleotidePrincipal Component AnalysisProtein D-Aspartate-L-Isoaspartate MethyltransferaseRepressor ProteinsCarrier ProteinsCOL11A1 protein, humanCollagen Type XIPLEKHA7 protein, humanProtein D-Aspartate-L-Isoaspartate MethyltransferaseRepressor ProteinsST18 protein, human
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