SynthesisNeuro-degenerative diseases2013
Consistent neurodegeneration and its association with clinical progression in Huntington's disease: a coordinate-based meta-analysis.
Synthesis in Neuro-degenerative diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Systemic Symptoms in Huntington's Disease: A Comprehensive Review.Movement disorders clinical practice · 2024Pooled it
- Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease.NeuroImage. Clinical · 2015Pooled it
- Meta-analysis in human neuroimaging: computational modeling of large-scale databases.Annual review of neuroscience · 2014Pooled it
- Trial
- Stage-Dependent Inhibitory Connectivity in Striatal-Motor Circuit in Huntington's Disease.Annals of clinical and translational neurology · 2025Article
- Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease.Inflammation and regeneration · 2024Article
- Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases.Advances in neurobiology · 2024Article
- Measuring cognitive impairment and monitoring cognitive decline in Huntington's disease: a comparison of assessment instruments.Journal of neurology · 2023Article
- Investigating the heterogeneity within the somatosensory-motor network and its relationship with the attention and default systems.PNAS nexus · 2023Article
- From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research.International journal of molecular sciences · 2023Review
- Autonomic dysfunction in Huntington's disease: AJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study.EBioMedicine · 2021Article
- Dissociable Motivational Deficits in Pre-manifest Huntington's Disease.Cell reports. Medicine · 2020Article
- Utility of the Parkinson's disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington's disease.Journal of neurology · 2020Article
- Structural brain correlates of dementia in Huntington's disease.NeuroImage. Clinical · 2020Article
- Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes.NeuroImage. Clinical · 2020Article
- Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach.Neuropsychiatric disease and treatment · 2019Review
- Cortical neurodevelopment in pre-manifest Huntington's disease.NeuroImage. Clinical · 2019Article
- Progressive microstructural changes of the occipital cortex in Huntington's disease.Brain imaging and behavior · 2018Article
- Risk factors of suicidal ideation in Huntington's disease: literature review and data from Enroll-HD.Journal of neurology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe neuropathological hallmark of Huntington's disease (HD) is progressive striatal loss starting several years prior to clinical onset. In the past decade, whole-brain magnetic resonance imaging (MRI) studies have provided accumulating evidence for widely distributed cortical and subcortical atrophy in the early course of the disease.
objectiveIn order to synthesize current morphometric MRI findings and to investigate the impact of clinical and genetic features on structural changes, we performed a coordinate-based meta-analysis of voxel-based morphometry (VBM) studies in HD.
methodsTwenty HD samples derived from 17 studies were integrated in the analysis comparing a total of 685 HD mutation carriers [345 presymptomatic (pre-HD) and 340 symptomatic (symp-HD) subjects] and 507 controls. Convergent findings across studies were delineated using the anatomical likelihood estimation approach. Effects of genetic and clinical parameters on the likelihood of observing VBM findings were calculated by means of correlation analyses.
resultsPre-HD studies featured convergent evidence for neurodegeneration in the basal ganglia, amygdala, thalamus, insula and occipital regions. In symp-HD, cerebral atrophy was more pronounced and spread to cortical regions (i.e., inferior frontal, premotor, sensorimotor, midcingulate, frontoparietal and temporoparietal cortices). Higher cytosine-adenosine-guanosine repeats were associated with striatal degeneration, while parameters of disease progression and motor impairment additionally correlated with cortical atrophy, especially in sensorimotor areas.
conclusionThis first quantitative meta-analysis in HD demonstrates the extent of striatal atrophy and further consistent extrastriatal degeneration before clinical conversion. Sensorimotor areas seem to be core regions affected in symp-HD and, along with widespread cortical atrophy, may account for the clinical heterogeneity in HD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.