ArticleDementia and geriatric cognitive disorders2012
Comparing hippocampal atrophy in Alzheimer's dementia and dementia with lewy bodies.
Article in Dementia and geriatric cognitive disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Machine learning classification and regional differentiation of neuropathologically-confirmed Alzheimer's disease and comorbid Lewy body disease.Communications medicine · 2026Article
- The role ofFrontiers in neuroscience · 2025Review
- Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases.Neurology · 2024Observational
- Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior.bioRxiv : the preprint server for biology · 2023Article
- Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer's Disease.Journal of clinical medicine · 2022Article
- Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology · 2022Review
- Article
- The development of new method to differentiate between Dementia with Lewy bodies and Alzheimer's disease by cerebral perfusion SPECT-comparison to CIScore.Japanese journal of radiology · 2021Article
- Molecular mechanisms in Alzheimer's disease and the impact of physical exercise with advancements in therapeutic approaches.AIMS neuroscience · 2021Review
- Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies.Frontiers in neurology · 2021Article
- Hippocampal subfields and decline in activities of daily living in Alzheimer's disease and dementia with Lewy bodies.Neurodegenerative disease management · 2020Article
- Differential Atrophy in the Hippocampal Subfield Volumes in Four Types of Mild Dementia.Frontiers in neuroscience · 2020Article
- In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies.Neurobiology of aging · 2019Article
- Use of Ceftriaxone in Treating Cognitive and Neuronal Deficits Associated With Dementia With Lewy Bodies.Frontiers in neuroscience · 2019Article
- Cortical Gray Matter and Hippocampal Atrophy in Idiopathic Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2019Article
- Neuroimaging in Lewy body dementia.Journal of neurology · 2019Review
- Role of Neuroimaging on Differentiation of Parkinson's Disease and Its Related Diseases.Yonago acta medica · 2018Review
- Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies.International psychogeriatrics · 2017Article
- Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer's disease dementia.Journal of neurology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
Abstract
BACKGROUND/
aimsDementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common neurodegenerative dementias. During the early stages, clinical distinction between them is often challenging. Our objective is to compare hippocampal atrophy patterns in mild AD and mild DLB. We hypothesized that DLB subjects have milder hippocampal atrophy relative to AD subjects.
methodsWe analyzed the T1-weighted magnetic resonance imaging data from 113 subjects: 55 AD, 16 DLB and 42 cognitively normal elderly (normal controls, NC). Using the hippocampal radial distance technique and multiple linear regression, we analyzed the effect of clinical diagnosis on hippocampal radial distance, while adjusting for gender and age. Three-dimensional statistical maps were adjusted for multiple comparisons using permutation-based statistics with a threshold of p < 0.01.
resultsCompared to NC, AD exhibited significantly greater atrophy in the cornu ammonis (CA)1, CA2-3 and subicular regions bilaterally while DLB showed left-predominant atrophy in the CA1 region and subiculum. Compared directly, AD and DLB did not reveal statistically significant differences.
conclusionHippocampal atrophy, while present in mildly impaired DLB subjects, is less severe than atrophy seen in mildly impaired AD subjects, when compared to NC. Both groups show predominant atrophy of the CA1 subfield and subiculum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.