Evidence map›Paper›PMID 22922554›Full record

Trial reportChest2013

Benefits of intensive treadmill exercise training on cardiorespiratory function and quality of life in patients with pulmonary hypertension.

Leighton Chan, Lisa M K Chin, Michelle Kennedy, Joshua G Woolstenhulme, Steven D Nathan, Ali A Weinstein, Gerilynn Connors, Nargues A Weir, Bart Drinkard, James Lamberti and 1 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 10 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00678821 phase2completednot on this map

Response and Adaptation to Aerobic Exercise in Patients With Pulmonary Hypertension: Initial Studies for Establishing Guidelines

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2008 to 2015Enrolled97ConditionsPulmonary Hypertension, Interstitial Lung DiseaseArmsAerobic exercise
NCT02019641 nacompletednot on this mapstarted 2015, after this paper: background citation

The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2015 to 2023Enrolled46ConditionsInterstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Interstitial Pneumonitis, Desquamative Interstitial PneumoniaArmsAerobic Exercise Training (AET), Education
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 10 syntheses or guidelines pooled it, 212 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
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  5. Exercise-based rehabilitation programmes for pulmonary hypertension.The Cochrane database of systematic reviews · 2023
    Pooled it
  6. Walking for hypertension.The Cochrane database of systematic reviews · 2021
    Pooled it
  7. Pooled it
  8. Exercise-based rehabilitation programmes for pulmonary hypertension.The Cochrane database of systematic reviews · 2017
    Pooled it
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  10. Pooled it
  11. Trial
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  18. Article
  19. Physical exercise for pulmonary arterial hypertension diagnosis and therapy.International journal of cardiology. Congenital heart disease · 2025
    Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Leighton ChanRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD. Electronic address: chanle@cc.nih.gov.
Lisa M K ChinRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD.
Michelle KennedyRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD.
Joshua G WoolstenhulmeRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD; Department of Rehabilitation Science, George Mason University, Fairfax, VA.
Steven D NathanDepartment of Medicine, Inova Fairfax Hospital, Falls Church, VA.
Ali A WeinsteinDepartment of Rehabilitation Science, George Mason University, Fairfax, VA.
Gerilynn ConnorsPulmonary Rehabilitation Center, Inova Fairfax Hospital, Falls Church, VA.
Nargues A WeirDepartment of Medicine, Inova Fairfax Hospital, Falls Church, VA.
Bart DrinkardRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD.
James LambertiDepartment of Medicine, Inova Fairfax Hospital, Falls Church, VA.
Randall E KeyserRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD; Department of Rehabilitation Science, George Mason University, Fairfax, VA.
National Institutes of Health · USInova Fairfax Hospital · USGeorge Mason University · US

Funding

Response to Aerobic Exercise in Patients with Pulmonary HypertensionZ01CL060068 · CLC · CLINICAL CENTER · PI CHAN, LEIGHTON · 2008 to 2008
$55k
Response to Aerobic Exercise in Patients with Pulmonary HypertensionZIACL060068 · CLC · CLINICAL CENTER · PI CHAN, LEIGHTON · 2009 to 2024
$0k
CLC NIH HHS 1 Z01 CL060068-05
6 · The paper itself

Abstract

backgroundPulmonary hypertension (PH) restricts the ability to engage in physical activity and decreases longevity. We examined the impact of aerobic exercise training on function and quality of life in patients with World Health Organization group 1 PH.

methodsPatients were randomized to a 10-week education only (EDU) or education/exercise combined (EXE) group. The exercise program consisted of 24-30 sessions of treadmill walking for 30-45 min per session at 70% to 80% of heart rate reserve. Outcome variables included changes in 6-min walk test (6MWT) distance, time to exercise intolerance, peak work rate (WR) from a cardiopulmonary treadmill test, and quality-of-life measures, including the Short Form Health Survey, version 2 (SF-36v2) and Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR).

resultsData are presented as mean SD. Twenty-three women (age, 54 11 years; BMI, 31 7 kg/m 2 ) were randomized to the EDU (n 5 13) or EXE (n 5 10) groups. Following 10 weeks of intervention, patients in the EXE group demonstrated an improvement in 6MWT distance (56 45 m; P 5 .002), increased time to exercise intolerance (1.9 1.3 min; P 5 .001), and peak WR (26 23 W; P 5 .004). Additionally, the EXE group scored significantly ( P , .050) better on six of the eight scales on SF-36v2, and fi ve of the six scales on CAMPHOR. In contrast, no significant improvement was observed for any of the outcome measures following EDU. No adverse events were noted in either group.

conclusionTen weeks of brisk treadmill walking improved 6MWT distance, cardiorespiratory function, and patient-reported quality of life in female patients with group 1 PH.

Indexed as

Exercise TherapyQuality of LifeWalkingAdultAgedCardiovascular SystemExercise ToleranceFemaleHeart RateHumansHypertension, PulmonaryMiddle AgedOutcome Assessment, Health CarePatient Education as TopicRespiratory SystemTreatment Outcome

Identifiers

PMID22922554
PMCPMC3566994
OpenAlexW2044477824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.