ArticleNature nanotechnology2012
Single-protein nanomechanical mass spectrometry in real time.
Article in Nature nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
What it found
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Who cites it
111 citing papers in PubMed.
- Millisecond phonon lifetimes in piezoelectric nanomechanical resonators.Nature nanotechnology · 2026Article
- Nanosecond, Nanometer Movies of MEMS/NEMS Dynamics in a Standard SEM Using Time-Tagged Secondary Electrons.Small methods · 2026Article
- Impact of Surface Effects on Support-Loss Mechanisms in Micro-/Nano-Beam Resonators.Nanomaterials (Basel, Switzerland) · 2026Article
- Evaluation of Surface Acoustic Wave Nebulization for NEMS Mass Spectrometry.Journal of mass spectrometry : JMS · 2026Article
- Resolving Abrikosov vortex entry in superconducting nanostring resonators via displacement-noise spectroscopy in cavity optomechanics.Nature communications · 2026Article
- Design and Simulation of a Mass Sensor Using Nanoscale HfNanomaterials (Basel, Switzerland) · 2026Article
- Acoustic Signal-Based Piezoelectric Thin-Film Microbalance: A Versatile and Portable Platform for Biomedical Sensing and Point-of-Care Testing.Biosensors · 2026Article
- Dispersive coupling and dual-mode sensing of a micromechanical resonator.Microsystems & nanoengineering · 2026Article
- Multiparametric quantification of bacterial cells using digital holographic microscopy.Scientific reports · 2025Article
- Mass and stiffness sensing performance of nanomechanical resonators: viability of infectious virus detection.Discover nano · 2025Article
- Diamond Molecular Balance: Ultra-Wide Range Nanomechanical Mass Spectrometry from MDa to TDa.Nano letters · 2025Article
- Localized topological states beyond Fano resonances via counter-propagating wave mode conversion in piezoelectric microelectromechanical devices.Nature communications · 2024Article
- Data-driven fingerprint nanoelectromechanical mass spectrometry.Nature communications · 2024Article
- Engineering error correcting dynamics in nanomechanical systems.Scientific reports · 2024Article
- Mass and Stiffness Deconvolution in Nanomechanical Resonators for Precise Mass Measurement and In Vivo Biosensing.ACS nano · 2024Article
- Amplifiable protein identification via residue-resolved barcoding and composition code counting.National science review · 2024Article
- Continuum Robots and Magnetic Soft Robots: From Models to Interdisciplinary Challenges for Medical Applications.Micromachines · 2024Review
- Dielectric Detection of Single Nanoparticles Using a Microwave Resonator Integrated with a Nanopore.ACS omega · 2024Article
- Nanomechanical mass measurements through feature-based time series clustering.The Review of scientific instruments · 2024Article
- Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Nanoelectromechanical systems (NEMS) resonators can detect mass with exceptional sensitivity. Previously, mass spectra from several hundred adsorption events were assembled in NEMS-based mass spectrometry using statistical analysis. Here, we report the first realization of single-molecule NEMS-based mass spectrometry in real time. As each molecule in the sample adsorbs on the resonator, its mass and position of adsorption are determined by continuously tracking two driven vibrational modes of the device. We demonstrate the potential of multimode NEMS-based mass spectrometry by analysing IgM antibody complexes in real time. NEMS-based mass spectrometry is a unique and promising new form of mass spectrometry: it can resolve neutral species, provide a resolving power that increases markedly for very large masses, and allow the acquisition of spectra, molecule-by-molecule, in real time.
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Registered trials
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