ArticleEuropean heart journal2012
Women and men with stable coronary artery disease have similar clinical outcomes: insights from the international prospective CLARIFY registry.
Article in European heart journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome.The Cochrane database of systematic reviews · 2020Pooled it
- Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome.The Cochrane database of systematic reviews · 2018Pooled it
- Definitions of peri-procedural myocardial infarction and the association with one-year mortality: Insights from CHAMPION trials.International journal of cardiology · 2018Trial
- Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease.Cardiovascular drugs and therapy · 2013Trial
- Effects of moderate physical training program in post-myocardial infarction patients with arterial hypertension.European journal of translational myology · 2025Article
- Impact of the Naples Prognostic Score at admission on long-term prognosis among patients with coronary artery disease.Frontiers in immunology · 2025Article
- Sex Differences in Cardiac Tolerance to Oxygen Deprivation - 40 Years of Cardiovascular Research.Physiological research · 2024Review
- A comparison of the management and five-year outcomes of patients treated for chronic coronary syndrome between 2006-2007 and 2015-2016 - insights from the PRESAGE registry.Cardiology journal · 2024Observational
- Management of Residual Risk in Chronic Coronary Syndromes. Clinical Pathways for a Quality-Based Secondary Prevention.Journal of clinical medicine · 2023Review
- Sex difference in the association of the triglyceride glucose index with obstructive coronary artery disease.Scientific reports · 2023Article
- Effectiveness and Tolerability of Bisoprolol/Perindopril Single-Pill Combination in Patients with Arterial Hypertension and a History of Myocardial Infarction: The PRIDE Observational Study.Advances in therapy · 2023Observational
- Sex-related impact on clinical outcomes of patients treated with drug-eluting stents according to clinical presentation: Patient-level pooled analysis from the GRAND-DES registry.Cardiology journal · 2023Article
- Review
- Are we any WISER yet? Progress and contemporary need for smart trials to include women in coronary artery disease trials.Contemporary clinical trials · 2022Review
- Procedural Outcomes in Patients Treated with Percutaneous Coronary Interventions within Chronic Total Occlusions Stratified by Gender.Journal of clinical medicine · 2022Article
- Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women.Biology · 2021Article
- Impact of Early Revascularization on Major Adverse Cardiovascular Events in Relation to Automatically Quantified Ischemia.JACC. Cardiovascular imaging · 2021Article
- Sex differences in clinical outcomes after rotational atherectomy of calcified coronary stenoses: from multicenter registry.American journal of cardiovascular disease · 2021Article
- Use of risk scores to identify lower and higher risk subsets among COMPASS-eligible patients with chronic coronary syndromes. Insights from the CLARIFY registry.Clinical cardiology · 2021Article
- Real-Life Incident Atrial Fibrillation in Outpatients with Coronary Artery Disease.Journal of clinical medicine · 2020Article
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No grant is acknowledged in the PubMed record.
Abstract
aimsMen and women differ in terms of presentation and management in coronary artery disease (CAD). Whether these differences translate into different clinical outcomes in stable CAD is unclear. We analysed data from the international prospective CLARIFY registry to compare cardiovascular clinical outcomes in men and women with stable CAD. METHODS AND
resultsWe analysed 1-year outcomes in 30 977 outpatients with stable CAD [23 975 (77.4%) men; 7002 (22.6%) women]. Women were older than men, more likely to have hypertension and diabetes, and less likely to exercise or smoke. They had more frequent angina, but were less likely to have undergone diagnostic non-invasive testing or coronary angiography. Women received less optimized treatment for stable CAD. One-year outcomes were similar for men and women for the composite of cardiovascular death, non-fatal myocardial infarction, or stroke [adjusted rates 1.7 vs. 1.8%, respectively, odds ratio (OR) 0.93, 95% confidence interval (CI) 0.75-1.15]; all-cause death (adjusted 1.5 vs. 1.6%, OR: 0.91, 95% CI: 0.72-1.13); fatal or non-fatal myocardial infarction (adjusted 1.0 vs. 0.9%, OR: 0.81, 95 CI: 0.60-1.08); and cardiovascular death or non-fatal myocardial infarction (adjusted 1.4 vs. 1.4%, OR: 0.89, 95% CI: 0.70-1.12). Fewer women underwent revascularization (2.6 vs. 2.2%, OR: 0.77, 95% CI: 0.64-0.93), although appropriateness was not analysed.
conclusionThe risk profiles of women and men with stable CAD differ substantially. However, 1-year outcomes were similar. Fewer women underwent revascularization. Further research is needed to better understand gender determinants of outcome and devise strategies to minimize bias in the management and treatment of women.
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