ArticleStereotactic and functional neurosurgery2012
Weight change after globus pallidus internus or subthalamic nucleus deep brain stimulation in Parkinson's disease and dystonia.
Article in Stereotactic and functional neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Trial
- Active electrode location does not influence weight gain after subthalamic nucleus deep brain stimulation surgery in Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Target-Dependent Postoperative Weight Gain after Pallidothalamic Tractotomy versus Pallidotomy for Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Weight and survival after deep brain stimulation for Parkinson's disease.Parkinsonism & related disorders · 2023Article
- Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.Neurobiology of disease · 2021Article
- Weight Change After Subthalamic Nucleus Deep Brain Stimulation in Patients With Isolated Dystonia.Frontiers in neurology · 2021Article
- Analysis of factors associated with brittle response in patients with Parkinson's disease.Annals of clinical and translational neurology · 2020Article
- Height and weight changes after deep brain stimulation in patients with Parkinson disease: role of clinical subtypes.Heliyon · 2019Article
- Deep Brain Stimulation-Possible Treatment Strategy for Pathologically Altered Body Weight?Brain sciences · 2018Review
- Deep Brain Stimulation in Parkinson's Disease.Parkinson's disease · 2018Article
- Weight gain after subthalamic nucleus deep brain stimulation in Parkinson's disease is influenced by dyskinesias' reduction and electrodes' position.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Observational
- Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson's Disease Patients: Disease, Patient, and Surgical Factors.Parkinson's disease · 2017Article
- Update on Deep Brain Stimulation for Dyskinesia and Dystonia: A Literature Review.Neurologia medico-chirurgica · 2016Review
- Body weight gain in patients with bilateral deep brain stimulation for dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- DBSproc: An open source process for DBS electrode localization and tractographic analysis.Human brain mapping · 2016Article
- Mechanisms of body weight fluctuations in Parkinson's disease.Frontiers in neurology · 2014Review
- The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation.PloS one · 2014Article
- Challenges in PD Patient Management After DBS: A Pragmatic Review.Movement disorders clinical practiceReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWeight gain has been described in Parkinson's disease (PD) patients after subthalamic nucleus (STN) deep brain stimulation (DBS).
objectivesWe examined change in weight following DBS in both PD and dystonia patients to further investigate the role of disease and brain target (STN or globus pallidus internus, GPi) specificity.
methodsData was retrospectively collected on 61 PD DBS patients (STN n = 31 or GPi n = 30) and on 36 dystonia DBS patients (STN n = 9 and GPi n = 27) before and after surgery. Annual change in body mass index (BMI) was evaluated with nonparametric tests between groups and multiple quantile regression.
resultsPD patients treated with STN DBS had a small increase in median BMI while those with GPi had a small decrease in BMI. Dystonia patients treated with STN DBS had a greater increase in BMI per year compared to those treated with GPi DBS. Multivariable regression analyses for each disease showed little difference between targets in weight gain in those with PD, but STN target was strongly associated with weight gain in dystonia patients (STN vs. GPi, +7.99 kg, p = 0.012).
conclusionsOur results support previous reports of weight gain after DBS in PD. This is the first report to suggest a target-specific increase in weight following STN DBS in dystonia patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.