ArticleNeuroscience2012
Differential distribution of serotonin receptor subtypes in BNST(ALG) neurons: modulation by unpredictable shock stress.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.Translational psychiatry · 2026Article
- The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females.Neurobiology of stress · 2024Article
- Bed Nucleus of the Stria Terminalis (BNST) neurons containing the serotonin 5HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Bed Nucleus of the Stria Terminalis (BNST) neurons containing the serotonin 5HTbioRxiv : the preprint server for biology · 2023Article
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Chronic stress induces cell type-selective transcriptomic and electrophysiological changes in the bed nucleus of the stria terminalis.Neuropharmacology · 2019Article
- Role of the Bed Nucleus of the Stria Terminalis in PTSD: Insights From Preclinical Models.Frontiers in behavioral neuroscience · 2019Review
- Repeated shock stress facilitates basolateral amygdala synaptic plasticity through decreased cAMP-specific phosphodiesterase type IV (PDE4) expression.Brain structure & function · 2018Article
- Role of the bed nucleus of the stria terminalis in aversive learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Review
- The bed nucleus of the stria terminalis in drug-associated behavior and affect: A circuit-based perspective.Neuropharmacology · 2017Review
- A comparative analysis of the physiological properties of neurons in the anterolateral bed nucleus of the stria terminalis in the Mus musculus, Rattus norvegicus, and Macaca mulatta.The Journal of comparative neurology · 2017Article
- Attenuation of the anxiogenic effects of cocaine by 5-HTPsychopharmacology · 2017Article
- Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat.The Journal of comparative neurology · 2017Article
- Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders.Molecular psychiatry · 2016Review
- Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.Neuropharmacology · 2015Article
- Neuroanatomical dichotomy of sexual behaviors in rodents: a special emphasis on brain serotonin.Behavioural pharmacology · 2015Review
- Prenatal Stress Alters the Development of Socioemotional Behavior and Amygdala Neuron Excitability in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Role of bed nucleus of the stria terminalis and amygdala AMPA receptors in the development and expression of context conditioning and sensitization of startle by prior shock.Brain structure & function · 2014Article
- Acoustic trauma triggers upregulation of serotonin receptor genes.Hearing research · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The bed nucleus of the stria terminalis (BNST) plays a critical role in regulating the behavioral response to stress. Stressors that activate the BNST also activate serotonergic (5-HT) systems. Hence, maladaptive changes of 5-HT receptor expression may contribute to stress-induced anxiety disorders. The BNST contains three neuronal types, Type I-III neurons. However, little is known about 5-HT receptor subtypes mRNA expression in these neurons, or whether it can be modulated by stress. Whole-cell patch clamp recording from Type I-III neurons was used in conjunction with single cell reverse transcriptase polymerase chain reaction (RT-PCR) to characterize 5-HT receptor mRNA expression, and examine the effects of stress on this expression. We report that Type I neurons expressed mRNA transcripts predominantly for 5-HT(1A) and 5-HT(7) receptors. Type II neurons expressed transcripts for every 5-HT receptor except the 5-HT(2C) receptor. Type II neurons were divided into three sub-populations: Type IIA in which transcripts for 5-HT(3) and 5-HT(7) receptors predominate, Type IIB that mainly express 5-HT(1B) and 5-HT(4) receptor transcripts, and Type IIC in which transcripts for 5-HT(1A) and 5-HT(2A) receptors predominate. Type III neurons were also subdivided into two sub-populations; one that predominantly expressed transcripts for 5-HT(1A), 5-HT(1B) and 5-HT(2A) receptors, and another that mainly expressed transcripts for 5-HT(2C) receptor. Unpredictable shock stress (USS) caused a long-lasting increase in anxiety-like behavior, and a concomitant decrease in 5-HT(1A) transcript expression in Type I-III neurons, as well as an up-regulation of a transcriptional repressor of 5-HT(1A) gene expression, deformed epidermal autoregulatory factor 1 (Deaf-1). Significantly USS decreased 5-HT(1A) protein level, and increased the level of Deaf-1. USS also increased 5-HT(1B) transcript expression in Type III neurons, as well as 5-HT(7) expression in Type I and II neurons. These data suggest that cell type-specific disruption of 5-HT receptor expression in BNST(ALG) neurons may contribute to stress-induced anxiety disorders.
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