ArticleNeuroscience2012
Ectopic uterine tissue as a chronic pain generator.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis.Journal of pain research · 2026Article
- Modelling Endometriosis Using In Vitro and In Vivo Systems.International journal of molecular sciences · 2025Review
- The relationship between pain intensity and insomnia in women with deep endometriosis, a cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Review
- Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.Biomedicines · 2022Article
- Review
- Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.Journal of neuroinflammation · 2021Article
- Relevant human tissue resources and laboratory models for use in endometriosis research.Acta obstetricia et gynecologica Scandinavica · 2017Review
- EPScientific reports · 2017Article
- Research Priorities for Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents.Molecular and cellular endocrinology · 2016Article
- Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats.European journal of pain (London, England) · 2016Article
- Impact of surgical excision of lesions on pain in a rat model of endometriosis.European journal of pain (London, England) · 2015Article
- Article
- Endometriosis: Survey of Current Diagnostic and Therapeutic Options and Latest Research Work.Geburtshilfe und Frauenheilkunde · 2014Article
- Screening the role of pronociceptive molecules in a rodent model of endometriosis pain.The journal of pain · 2014Article
- Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis.Neuroscience · 2014Article
- A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis In Montpellier, France.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Vascular endothelial cells mediate mechanical stimulation-induced enhancement of endothelin hyperalgesia via activation of P2X2/3 receptors on nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implanted with autologous uterus in the gastrocnemius muscle. Within two weeks, visual inspection revealed the presence of a reddish-brown fluid-filled cystic structure at the implant site. Histology demonstrated cystic glandular structures with stromal invasion of the muscle. Immunohistochemical studies of these lesions revealed the presence of markers for nociceptor nerve fibers and neuronal sprouting. Fourteen days after surgery rats exhibited persistent mechanical hyperalgesia at the site of the ectopic endometrial lesion. Intralesional, but not contralateral, injection of progesterone was dose-dependently antihyperalgesic. Systemic administration of leuprolide also produced antihyperalgesia. In vivo electrophysiological recordings from sensory neurons innervating the lesion revealed a significant increase in their response to sustained mechanical stimulation. These results are consistent with clinical and pathological findings observed in patients with endometriosis, compatible with the ectopic endometrium as a source of pain. This model of endometriosis allows mechanistic exploration at the lesion site facilitating our understanding of endometriosis pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.