ArticleCell2012
A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed.
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
- NUTCRACKER orchestrates cortical cell divisions and sustains stem cell niche integrity in the rice root meristem.Journal of experimental botany · 2026Article
- Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026Review
- Molecular regulation of asymmetric cell division in dicots: insights from Arabidopsis development.Molecular biology reports · 2025Review
- Stem cell regulators drive a G1 duration gradient during plant root development.Nature plants · 2025Article
- Out of the Niche: A Bird's-Eye View of the Molecular Networks Controlling Root Stem Cells.Plants (Basel, Switzerland) · 2025Review
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Algal origins of core land plant stress response subnetworks.The Plant journal : for cell and molecular biology · 2025Article
- Comprehensive analysis of the INDETERMINATE DOMAIN (IDD) gene family in Marchantia polymorpha brings new insight into evolutionary developmental biology.BMC genomics · 2025Article
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- A Strategy to Use Artificial MicroRNAs for Gene Silencing and Overcome (AmiGO).Methods in molecular biology (Clifton, N.J.) · 2025Article
- Integrative regulation of middle cortex formation: from classic modules to emerging pathways.Frontiers in plant science · 2025Review
- Rooting for survival: how plants tackle a challenging environment through a diversity of root forms and functions.Plant physiology · 2024Review
- The Identification and Characterization of WOX Family Genes inInternational journal of molecular sciences · 2024Article
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- Stem cell quiescence and dormancy in plant meristems.Journal of experimental botany · 2024Review
- Dual role of BdMUTE during stomatal development in the model grass Brachypodium distachyon.Development (Cambridge, England) · 2024Article
- What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.Annual review of cell and developmental biology · 2024Review
- Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning.The Plant journal : for cell and molecular biology · 2024Review
- BIG coordinates auxin and SHORT ROOT to promote asymmetric stem cell divisions in Arabidopsis roots.Plant cell reports · 2024Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a "flip flop" that constrains asymmetric cell division to the stem cell region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.