Evidence map›Paper›PMID 22921799›Full record

ArticleThe Journal of allergy and clinical immunology2013

The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06 ppm).

Neil E Alexis, John C Lay, Haibo Zhou, Chong S Kim, Michelle L Hernandez, Howard Kehrl, Milan J Hazucha, Robert B Devlin, David Diaz-Sanchez, David B Peden

Abstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Air pollution-induced airway epithelial barrier dysfunction in COPD: a narrative review of mechanisms and therapeutic implications.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Ozone in the Development of Pediatric Asthma and Atopic Disease.Immunology and allergy clinics of North America · 2022
    Review
  4. Article
  5. Article
  6. Air pollution and indoor settings.The World Allergy Organization journal · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects.American journal of physiology. Lung cellular and molecular physiology · 2014
    Article
  14. Update in environmental and occupational lung diseases 2013.American journal of respiratory and critical care medicine · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Neil E Alexis
John C Lay
Haibo Zhou
Chong S Kim
Michelle L Hernandez
Howard Kehrl
Milan J Hazucha
Robert B Devlin
David Diaz-Sanchez
David B Peden

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
The Mucus Transport Apparatus: Why Two Layers?P50HL084934 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2006 to 2010
$15.6M
P2X7 and the Inflammasome Pathways in Lung InflammationU19AI077437 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2008 to 2013
$9.2M
Ozone and LPS-Induced Airway Inflammation In Humans In VivoR01ES012706 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2004 to 2008
$1.5M
Investigating gene x environment interaction using human exposures to O3 & LPSRC1ES018417 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2009 to 2010
$977k
NHLBI NIH HHS P50 HL084934NIAID NIH HHS U19 AI077437NIAID NIH HHS U19AI077437NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES012706NIEHS NIH HHS R01ES012706NIEHS NIH HHS RC1 ES018417NIEHS NIH HHS RC1ES018417
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultCytokinesGenotypeGlutathione TransferaseHumansImmunity, InnateInflammationNeutrophilsOzonePhagocytosisRisk FactorsYoung AdultCytokinesGlutathione TransferaseOzone

Identifiers

PMID22921799
PMCPMC3509264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.