Trial reportPain2012
Experimental hypoglycemia is a human model of stress-induced hyperalgesia.
Trial report in Pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypoglycemia and Autonomic Nervous System Function
A Double-Blind, Randomized, Placebo-Controlled Trial To Evaluate The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial.The Journal of clinical endocrinology and metabolism · 2025Trial
- Mechanisms of "Cough-Trick" for Pain Relief during Venipuncture: An Experimental Crossover Investigation in Healthy Volunteers.Pain research & management · 2019Trial
- Strategies for optimization of hypoglycemia rat models.Animal models and experimental medicine · 2025Review
- Neuropathy of diabetes following initiation of a low-carbohydrate diet: Case report.Obesity pillars · 2024Article
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
- Impact of Intensive Glycemic Treatment on Diabetes Complications-A Systematic Review.Pharmaceutics · 2023Review
- Stress, hypoglycemia, and the autonomic nervous system.Autonomic neuroscience : basic & clinical · 2022Review
- The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain.Molecular pain · 2022Article
- The Impact of Hypoglycemia on Patients with Diabetes Mellitus: A Cross-Sectional Analysis.Journal of clinical medicine · 2022Article
- Feasibility, Efficacy, and Safety of Percutaneous Muscle Biopsies in Patients With Chronic Liver Disease.Frontiers in physiology · 2021Article
- GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABABMC anesthesiology · 2020Article
- Anxious anticipation and pain: the influence of instructed vs conditioned threat on pain.Social cognitive and affective neuroscience · 2017Article
- Pain in Times of Stress.The Malaysian journal of medical sciences : MJMS · 2015Article
- Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes.Brain : a journal of neurology · 2015Article
- Stress induces pain transition by potentiation of AMPA receptor phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Diabetic neuropathies.Continuum (Minneapolis, Minn.) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hypoglycemia is a physiological stress that leads to the release of stress hormones, such as catecholamines and glucocorticoids, and proinflammatory cytokines. These factors, in euglycemic animal models, are associated with stress-induced hyperalgesia. The primary aim of this study was to determine whether experimental hypoglycemia in humans would lead to a hyperalgesic state. In 2 separate 3-day admissions separated by 1 to 3 months, healthy study participants were exposed to two 2-hour euglycemic hyperinsulinemic clamps or two 2-hour hypoglycemic hyperinsulinemic clamps. Thermal quantitative sensory testing and thermal pain assessments were measured the day before and the day after euglycemia or hypoglycemia. In contrast to prior euglycemia exposure, prior hypoglycemia exposure resulted in enhanced pain sensitivity to hot and cold stimuli as well as enhanced temporal summation to repeated heat-pain stimuli. These findings suggest that prior exposure to hypoglycemia causes a state of enhanced pain sensitivity that is consistent with stress-induced hyperalgesia. This human model may provide a framework for hypothesis testing and targeted, mechanism-based pharmacological interventions to delineate the molecular basis of hyperalgesia and pain susceptibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.