ArticleBMC evolutionary biology2012
Accurate discrimination of bHLH domains in plants, animals, and fungi using biologically meaningful sites.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Properties of Putative APSES Transcription Factor AfpA inJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- Genome-Wide Characterization ofPlants (Basel, Switzerland) · 2023Article
- SbbHLH85, a bHLH member, modulates resilience to salt stress by regulating root hair growth in sorghum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Genome-Wide Identification and Characterization of the bHLH Transcription Factor Family in Pepper (Frontiers in genetics · 2020Article
- Article
- The Significance of the Intrinsically Disordered Regions for the Functions of the bHLH Transcription Factors.International journal of molecular sciences · 2019Review
- Beyond the Big Five: Investigating Myostatin Structure, Polymorphism and Expression inFrontiers in genetics · 2019Article
- Transcriptome-wide identification and expression profile analysis of the bHLH family genes in Camellia sinensis.Functional & integrative genomics · 2018Article
- OsMPK3 is a TEY-type rice MAPK in Group C and phosphorylates OsbHLH65, a transcription factor binding to the E-box element.Plant cell reports · 2014Article
- Evolution, functional divergence and conserved exon-intron structure of bHLH/PAS gene family.Molecular genetics and genomics : MGG · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe highly conserved bHLH (basic Helix-Loop-Helix) domain, found in many transcription factors, has been well characterized separately in Plants, Animals, and Fungi. While conserved, even functionally constrained sites have varied since the Eukarya split. Our research identifies those slightly variable sites that were highly characteristic of Plants, Animals, or Fungi.
resultsThrough discriminant analysis, we identified five highly discerning DNA-binding amino acid sites. Additionally, by incorporating Kingdom specific HMMs, we were able to construct a tool to quickly and accurately identify and classify bHLH sequences using these sites.
conclusionsWe conclude that highly discerning sites identified through our analysis were likely under functional constraints specific to each Kingdom. We also demonstrated the utility of our tool by identifying and classifying previously unknown bHLH domains in both characterized genomes and from sequences in a large environmental sample.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.