ReviewNeuron2012
The spike-timing dependence of plasticity.
Review in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 413 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
413 citing papers in PubMed.
- Paired associative stimulation improves outcomes when applied at the subacute stage after incomplete cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Combinatorial approaches increasing neuronal activity accelerate recovery after spinal cord injury.Brain : a journal of neurology · 2025Trial
- Multisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury.Annals of neurology · 2023Trial
- Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury.Brain : a journal of neurology · 2020Trial
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Irregular and bursty neuronal firing extend spike-timing dependent plasticity window to behavioral timescales.iScience · 2026Article
- Neural rhythms as priors of speech computations.Patterns (New York, N.Y.) · 2026Article
- Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- Article
- Theoretical analysis of low power synergistic sono-optogenetic control of calcium-dependent synaptic plasticity.Scientific reports · 2026Article
- The calcium-binding protein S100β regulates synaptic plasticity in the visual cortex.iScience · 2026Article
- Dynamical mechanisms for coordinating long-term working memory based on the precision of spike-timing in cortical neurons.Biological cybernetics · 2026Review
- Micro-Stimulation Timing Framed Around an Averaged Theta Period of Stimulation Determines Hippocampal Recruitment in Cued Fear Conditioning.Hippocampus · 2026Article
- Prolonged Visual Entrainment Induces Long-Lasting Alpha-Band Modulations.Psychophysiology · 2026Article
- Rapid formation of non-spatial hippocampal representations consistent with behavioral timescale synaptic plasticity is modulated by entorhinal input.Nature communications · 2026Article
- Cellular and subcellular specialization enables biology-constrained deep learning.Cell reports · 2026Article
- Intrinsic stabilization of synaptic plasticity improves learning and robustness in artificial neural networks.Nature communications · 2026Article
353 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
In spike-timing-dependent plasticity (STDP), the order and precise temporal interval between presynaptic and postsynaptic spikes determine the sign and magnitude of long-term potentiation (LTP) or depression (LTD). STDP is widely utilized in models of circuit-level plasticity, development, and learning. However, spike timing is just one of several factors (including firing rate, synaptic cooperativity, and depolarization) that govern plasticity induction, and its relative importance varies across synapses and activity regimes. This review summarizes this broader view of plasticity, including the forms and cellular mechanisms for the spike-timing dependence of plasticity, and, the evidence that spike timing is an important determinant of plasticity in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.