ReviewEpigenomics2012
The epigenetic lorax: gene-environment interactions in human health.
Review in Epigenomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Meta-analyses between 18 candidate genetic markers and overweight/obesity.Diagnostic pathology · 2014Pooled it
- Role of epigenetic in cancer biology, in hematologic malignancies and in anticancer therapy.Frontiers in molecular medicine · 2024Review
- Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation.PLoS genetics · 2023Article
- Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Identification of Mitochondrial Genome-Encoded Small RNAs Related to Egg Deterioration Caused by Postovulatory Aging in Rainbow Trout.Marine biotechnology (New York, N.Y.) · 2016Article
- Effects of long-term endocrine disrupting compound exposure on Macaca mulatta embryonic stem cells.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Environmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the Room.International journal of environmental research and public health · 2016Review
- The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Transgenerational effects of binge drinking in a primate model: implications for human health.Fertility and sterility · 2015Article
- Endoplasmic reticulum stress signaling in mammalian oocytes and embryos: life in balance.International review of cell and molecular biology · 2015Review
- Attention Deficit Hyperactivity Disorder in the Light of the Epigenetic Paradigm.Frontiers in psychiatry · 2015Review
- Genome-wide analysis of gestational gene-environment interactions in the developing kidney.Physiological genomics · 2014Article
- Effects of living at higher altitudes on mortality: a narrative review.Aging and disease · 2014Review
- Excess vitamin intake: An unrecognized risk factor for obesity.World journal of diabetes · 2014Article
- Improving cancer clinical research and trials with Hispanic populations: training and outreach efforts between Moffitt Cancer Center and the Ponce School of Medicine.Reviews on recent clinical trials · 2014Article
- Biomarker Development for Brain-Based Disorders: Recent Progress in Psychiatry.Journal of neurology and psychology · 2013Article
- Epigenetic findings in autism: new perspectives for therapy.International journal of environmental research and public health · 2013Review
- Nuclear reprogramming and its role in vascular smooth muscle cells.Current atherosclerosis reports · 2013Review
- The positive association of obesity variants with adulthood adiposity strengthens over an 80-year period: a gene-by-birth year interaction.Human heredity · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Over the last decade, we have witnessed an explosion of information on genetic factors underlying common human diseases and disorders. This 'human genomics' information revolution has occurred as a backdrop to a rapid increase in the rates of many human disorders and diseases. For example, obesity, Type 2 diabetes, asthma, autism spectrum disorder and attention deficit hyperactivity disorder have increased at rates that cannot be due to changes in the genetic structure of the population, and are difficult to ascribe to changes in diagnostic criteria or ascertainment. A likely cause of the increased incidence of these disorders is increased exposure to environmental factors that modify gene function. Many environmental factors that have epidemiological association with common human disorders are likely to exert their effects through epigenetic alterations. This general mechanism of gene-environment interaction poses special challenges for individuals, educators, scientists and public policy makers in defining, monitoring and mitigating exposures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.