Evidence map›Paper›PMID 22919703›Full record

ArticleChemical communications (Cambridge, England)2012

A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface.

Zhe Wang, Peng Huang, Ashwinkumar Bhirde, Albert Jin, Ying Ma, Gang Niu, Nouri Neamati, Xiaoyuan Chen

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 109 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Graphene Oxide-Based Nanomaterials: An Insight into Retinal Prosthesis.International journal of molecular sciences · 2020
    Review
  8. Review
  9. Biomedical Applications of Graphene-Based Structures.Nanomaterials (Basel, Switzerland) · 2018
    Review
  10. Review
  11. Article
  12. Graphene-based nanomaterials for bioimaging.Advanced drug delivery reviews · 2016
    Review
  13. Graphene: The Missing Piece for Cancer Diagnosis?Sensors (Basel, Switzerland) · 2016
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. DNA-guided metal-nanoparticle formation on graphene oxide surface.Advanced materials (Deerfield Beach, Fla.) · 2013
    Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Zhe WangCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China 361005.
Peng Huang
Ashwinkumar Bhirde
Albert Jin
Ying Ma
Gang Niu
Nouri Neamati
Xiaoyuan Chen
National Institutes of Health · USNational Institute of Biomedical Imaging and Bioengineering · USUniversity of Southern California · US

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Biomedical Studies and Cellular Imaging via Atomic Force MicroscopyZIAEB000015 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI JIN, ALBERT J · 2009 to 2025
$5.8M
Integrin avb3 targeted drug design, delivery, and imagingR01CA120188 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEAMATI, NOURI · 2007 to 2011
$1.1M
Intramural NIH HHS Z99 EB999999Intramural NIH HHS ZIA EB000015Intramural NIH HHS ZIA EB000073NCI NIH HHS R01CA120188
6 · The paper itself

Abstract

A nanoscale RGD-pyrene-graphene oxide (GO) biosensor was prepared for real-time in situ detection of a cancer cell surface marker, integrin αvβ3. This nanoscale GO-based biosensor is simple, robust, sensitive and of high selectivity. It can also be adapted to other cancer cell surface marker evaluation systems.

Indexed as

Biosensing TechniquesBiomarkersBreast NeoplasmsGraphiteHumansIntegrin alphaVbeta3MCF-7 CellsNanostructuresOligopeptidesOxidesPyrenesSurface PropertiesTime FactorsTumor Cells, Culturedarginyl-glycyl-aspartic acidBiomarkersGraphiteIntegrin alphaVbeta3OligopeptidesOxidespyrenePyrenes

Identifiers

PMID22919703
PMCPMC3622590
OpenAlexW2042245324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.