Evidence map›Paper›PMID 22919592›Full record

ReviewFrontiers in cellular and infection microbiology2011

The promise of bacteriophage therapy for Burkholderia cepacia complex respiratory infections.

Diana D Semler, Karlene H Lynch, Jonathan J Dennis

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Microorganisms · 2025
    Review
  4. Phage therapy: breathing new tactics into lower respiratory tract infection treatments.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  5. Phage therapy to treat cystic fibrosisFrontiers in microbiology · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Encapsulation and Delivery of Therapeutic Phages.Applied and environmental microbiology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Effect of storage temperature on the stability of spray dried bacteriophage powders.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2018
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Diana D SemlerDepartment of Biological Sciences, Centennial Centre for Interdisciplinary Science, University of Alberta Edmonton, AB, Canada.
Karlene H Lynch
Jonathan J Dennis
University of Alberta · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

In recent times, increased attention has been given to evaluating the efficacy of phage therapy, especially in scenarios where the bacterial infectious agent of interest is highly antibiotic resistant. In this regard, phage therapy is especially applicable to infections caused by the Burkholderia cepacia complex (BCC) since members of the BCC are antibiotic pan-resistant. Current studies in BCC phage therapy are unique from many other avenues of phage therapy research in that the investigation is not only comprised of phage isolation, in vitro phage characterization and assessment of in vivo infection model efficacy, but also adapting aerosol drug delivery techniques to aerosol phage formulation delivery and storage.

Indexed as

Burkholderia cepacia complexAerosolsAnimalsBacteriophagesBiological TherapyBurkholderia InfectionsFreeze DryingHumansMyoviridaePodoviridaePowdersRespiratory Tract InfectionsSiphoviridaeAerosolsPowdersaerosolsanimal infection modelsbacteriophageBurkholderiaBurkholderia cepacia complexdry powder inhalerslung infectionsphage therapy

Identifiers

PMID22919592
PMCPMC3417384
OpenAlexW2068839450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.