Evidence map›Paper›PMID 22919571›Full record

ReviewFrontiers in cellular and infection microbiology2011

Structure and function of the Haemophilus influenzae autotransporters.

Nicole A Spahich, Joseph W St Geme

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Journal of bacteriology · 2026
    Review
  2. Advances in adhesion-related pathogenesis inFrontiers in microbiology · 2025
    Review
  3. Article
  4. Review
  5. Highly Similar Sequences of Mature IgA1 Proteases fromPathogens (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Article
  8. Genomic Analysis ofMicroorganisms · 2021
    Article
  9. Article
  10. Review
  11. Frontiers in microbiology · 2020
    Article
  12. Review
  13. Review
  14. Article
  15. How bacteria hack the matrix and dodge the bullets of immunity.European respiratory review : an official journal of the European Respiratory Society · 2018
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicole A SpahichDepartment of Pediatrics, Children's Health Center, Duke University Medical Center Durham, NC, USA.
Joseph W St Geme
Duke Medical Center · US

Funding

BIOLOGY OF THE HMW2 AND HMW2 ADHESINS OF H INFLUENZAER01DC002873 · NIDCD · WASHINGTON UNIVERSITY · PI ST. GEME, JOSEPH W. · 1995 to 2014
$4.4M
NIDCD NIH HHS R01 DC002873
6 · The paper itself

Abstract

Autotransporters are a large class of proteins that are found in the outer membrane of Gram-negative bacteria and are almost universally implicated in virulence. These proteins consist of a C-terminal β-domain that is embedded in the outer membrane and an N-terminal domain that is exposed on the bacterial surface and is endowed with effector function. In this article, we review and compare the structural and functional characteristics of the Haemophilus influenzae IgA1 protease and Hap monomeric autotransporters and the H. influenzae Hia and Hsf trimeric autotransporters. All of these proteins play a role in colonization of the upper respiratory tract and in the pathogenesis of H. influenzae disease.

Indexed as

Adhesins, BacterialBacterial AdhesionBacterial Outer Membrane ProteinsHaemophilus InfectionsHaemophilus influenzaeHumansModels, MolecularProtein Structure, QuaternaryProtein Structure, TertiarySerine EndopeptidasesVirulenceAdhesins, BacterialBacterial Outer Membrane ProteinsHap protein, Hemophilus influenzaeHia adhesinHsf protein, bacteriaIgA-specific serine endopeptidaseSerine EndopeptidasesadhesinautotransporterHaemophilus influenzaeserine protease

Identifiers

PMID22919571
PMCPMC3417375
OpenAlexW2058942385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.