ArticleEvidence-based complementary and alternative medicine : eCAM2012
Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 4 syntheses or guidelines pooled it, 290 citations in OpenAlex.
- Cold pressed oils: a systematic review on physicochemical properties, nutritional composition and pharmacological activities.Frontiers in nutrition · 2026Pooled it
- Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review.Frontiers in veterinary science · 2025Pooled it
- Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens.Current topics in medicinal chemistry · 2019Pooled it
- Medicinal plants--prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review.BMC veterinary research · 2016Pooled it
- Carvacrol Modulates Cadmium-Induced Behavioral, Biochemical, Histopathological, and Metabolomic Alterations in rats.Biological trace element research · 2026Article
- Thyme Essential Oil and Hyaluronic Acid as Natural Disinfectant Alternatives for Broiler Breeder Fertile Eggs: Effects on Eggshell Microbial Load, Embryonic Viability and Hatchability.Veterinary medicine and science · 2026Article
- Thymol modulates rumen barrier function and inflammation in feed-restricted lambs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Chemical Composition and Biological Activities of Bulgarian Thyme (Current issues in molecular biology · 2026Article
- Apoptosis and Cell Cycle Dysregulation in AmpligoJournal of xenobiotics · 2026Article
- Multimodal Topical Formulations Combining Synthetic Anti-Inflammatory Agents, Levofloxacin, and Plant Extracts for Veterinary Wound and Inflammation Care: In Vivo Efficacy.Veterinary sciences · 2026Article
- Exploration of the Phytochemical and Antidiabetic Properties of Teucrium polium: A Natural Asset for Type 2 Diabetes Management.ChemistryOpen · 2026Article
- Chemical Composition and Biological Activity of Essential Oil fromMolecules (Basel, Switzerland) · 2026Article
- Carvacrol as a one health-relevant antimicrobial agent: mechanistic insights on its impact on gnotobiotic Artemia and Vibrio campbellii interactions.Frontiers in immunology · 2026Article
- The Rising Threat of Antibiotic Resistance in Poultry: Veterinary and One Health Perspectives.Veterinary sciences · 2025Review
- Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol.Current issues in molecular biology · 2025Review
- Polymer-Based Scaffolds Incorporating Selected Essential Oil Components for Wound Healing: A Review.Pharmaceutics · 2025Review
- Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies.Food science & nutrition · 2025Article
- The effect of thyme essential oil on duodenal toxicity induced by subacute exposure to voliam targo® insecticide in male rabbits.Toxicology reports · 2025Article
- A Mixture of Free and Microencapsulated Essential Oils Combined with Turmeric and Tannin in the Diet of Dairy Cows: Effects on Productive Efficiency and Animal Health.Animals : an open access journal from MDPI · 2025Article
- Role of Microencapsulated Essential Oil and Pepper Resin in the Diet of Cows in the Third Lactation Phase on Immunological Pathways.Veterinary sciences · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyme (Thymus vulgaris L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. The effect of Thymus vulgaris essential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and chemotaxis in vitro. In the pleurisy model, TEO, CVL, and thymol significantly inhibited inflammatory edema. However, only TEO and CVL inhibited leukocyte migration. In the in vitro chemotaxis experiment, CVL inhibited leukocyte migration, whereas thymol exerted a potent chemoattractant effect. In the ear edema model, CVL (10 mg/ear), applied topically, reduced edema formation, exerting a topical anti-inflammatory effect. Thymol did not reduce edema formation but rather presented an irritative response, probably dependent on histamine and prostanoid release. Our data suggest that the antiinflammatory effects of TEO and CVL are attributable to the inhibition of inflammatory edema and leukocyte migration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.