ArticleEvidence-based complementary and alternative medicine : eCAM2012
From omics to drug metabolism and high content screen of natural product in zebrafish: a new model for discovery of neuroactive compound.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Oral Administration of Liposomal Resveratrol for Wound Healing in a Zebrafish Model.Molecules (Basel, Switzerland) · 2026Article
- Ethanolic Extract ofInternational journal of molecular sciences · 2026Article
- Artificial Intelligence for Natural Products Drug Discovery in Neurodegenerative Therapies: A Review.Biomolecules · 2026Review
- Zebrafish as a translational filter for natural sleep modulators.Frontiers in nutrition · 2026Review
- TnP as a Multifaceted Therapeutic Peptide with System-Wide Regulatory Capacity.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Zebrafish in the spotlight: expanding Frontiers in toxicology and drug discovery.Toxicology research · 2025Review
- Evaluation of natural products bioactivity in cardiovascular diseases utilizing zebrafish models: a comprehensive review.Frontiers in pharmacology · 2025Review
- Advances in Zebrafish as a Comprehensive Model of Mental Disorders.Depression and anxiety · 2023Review
- Bioprospecting of Less-Polar Fractions ofMarine drugs · 2022Article
- Article
- Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish.Frontiers in pharmacology · 2022Article
- Zebrafish as a Model for In-Depth Mechanistic Study for Stroke.Translational stroke research · 2021Review
- Preclinical Toxicity and Safety of MM-129-First-in-Class BTK/PD-L1 Inhibitor as a Potential Candidate against Colon Cancer.Pharmaceutics · 2021Article
- Mass spectrometry imaging in zebrafish larvae for assessing drug safety and metabolism.Analytical and bioanalytical chemistry · 2021Article
- Label-free photoacoustic microscopy: a potential tool for the live imaging of blood disorders in zebrafish.Biomedical optics express · 2021Article
- Neurobiological effects of phospholipidsNeurobiology of stress · 2020Article
- Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis.Frontiers in pharmacology · 2020Article
- Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Absence of histopathological changes in the retina of zebrafish treated with sodium iodate.The Journal of veterinary medical science · 2018Article
- Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zebrafish (Danio rerio) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening. Zebrafish has emerged as a biomedically relevant model for in vivo high content drug screening and the simultaneous determination of multiple efficacy parameters, including behaviour, selectivity, and toxicity in the content of the whole organism. A zebrafish behavioural assay has been demonstrated as a novel, rapid, and high-throughput approach to the discovery of neuroactive, psychoactive, and memory-modulating compounds. Recent studies found a functional similarity of drug metabolism systems in zebrafish and mammals, providing a clue with why some compounds are active in zebrafish in vivo but not in vitro, as well as providing grounds for the rationales supporting the use of a zebrafish screen to identify prodrugs. Here, we discuss the advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches. Why this model is suitable for identifying lead compounds from natural products for therapy of disorders with multifactorial etiopathogenesis and imbalance of angiogenesis, such as Parkinson's disease, epilepsy, cardiotoxicity, cerebral hemorrhage, dyslipidemia, and hyperlipidemia, is addressed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.