ReviewClinical & developmental immunology2012
Morphologic features of extrahepatic manifestations of hepatitis C virus infection.
Review in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02825212 (Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review.World journal of gastroenterology · 2015Pooled it
- Seroepidemiological Prevalence of Hepatitis B and C Virus Coinfection: A Large-Scale Retrospective Cohort Study in Istanbul.Diagnostics (Basel, Switzerland) · 2026Article
- The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population.Clinical and experimental medicine · 2024Article
- First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report.BMC infectious diseases · 2021Article
- Real-world direct-acting antiviral treatment in kidney transplant and hemodialysis patients: the EpiTer-2 multicenter observational study.Annals of gastroenterology · 2021Article
- HCV Extrahepatic Manifestations.Journal of clinical and translational hepatology · 2019Review
- Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report.World journal of hepatology · 2019Article
- Hepatitis C Virus and Nonliver Solid Cancers: Is There an Association between HCV and Cancers of the Pancreas, Thyroid, Kidney, Oral Cavity, Breast, Lung, and Gastrointestinal Tract?Gastroenterology research and practice · 2017Review
- Hepatitis C virus as a systemic disease: reaching beyond the liver.Hepatology international · 2016Review
- Hepatitis C genotype 4: The past, present, and future.World journal of hepatology · 2015Review
- Abnormal CD4 + T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection.Virology journal · 2015Article
- Dermatologic Extrahepatic Manifestations of Hepatitis C.Journal of clinical and translational hepatology · 2015Review
- Prevalence and risk factors for patient-reported joint pain among patients with HIV/hepatitis C coinfection, hepatitis C monoinfection, and HIV monoinfection.BMC musculoskeletal disorders · 2015Article
- Cutaneous manifestations of viral hepatitis.Current infectious disease reports · 2015Article
- HCV, but not HIV, is a risk factor for cerebral small vessel disease.Neurology(R) neuroimmunology & neuroinflammation · 2014Article
- Extrahepatic immune related manifestations in chronic hepatitis C virus infection.World journal of gastroenterology · 2014Review
- Role of macrophages and monocytes in hepatitis C virus infections.World journal of gastroenterology · 2014Review
- Association of oral lichen planus with chronic C hepatitis. Review of the data in literature.Maedica · 2014Review
- Prevalence of type 2 diabetes mellitus in hepatitis C virus infected population: a Southeast Asian study.Journal of diabetes research · 2013Article
- Zinc-responsive acral hyperkeratotic dermatosis-A novel entity or a subset of some well-known dermatosis?Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cirrhosis and hepatocellular carcinoma are the prototypic complications of chronic hepatitis C virus infection in the liver. However, hepatitis C virus also affects a variety of other organs that may lead to significant morbidity and mortality. Extrahepatic manifestations of hepatitis C infection include a multitude of disease processes affecting the small vessels, skin, kidneys, salivary gland, eyes, thyroid, and immunologic system. The majority of these conditions are thought to be immune mediated. The most documented of these entities is mixed cryoglobulinemia. Morphologically, immune complex depositions can be identified in small vessels and glomerular capillary walls, leading to leukoclastic vasculitis in the skin and membranoproliferative glomerulonephritis in the kidney. Other HCV-associated entities include porphyria cutanea tarda, lichen planus, necrolytic acral erythema, membranous glomerulonephritis, diabetic nephropathy, B-cell non-Hodgkin lymphomas, insulin resistance, sialadenitis, sicca syndrome, and autoimmune thyroiditis. This paper highlights the histomorphologic features of these processes, which are typically characterized by chronic inflammation, immune complex deposition, and immunoproliferative disease in the affected organ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.