ArticleTheScientificWorldJournal2012
Spectroscopic evaluation of glioma grading at 3T: the combined role of short and long TE.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimal differentiation of high- and low-grade glioma and metastasis: a meta-analysis of perfusion, diffusion, and spectroscopy metrics.Neuroradiology · 2016Pooled it
- Histopathology-correlated evaluation of magnetic resonance spectroscopy for high-grade glioma prediction: A small-scale neuro-oncology study with exploratory machine learning.IBRO neuroscience reports · 2026Article
- Grading of Gliomas by Contrast-Enhanced CT Radiomics Features.Journal of biomedical physics & engineering · 2024Article
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- Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions.Current medical imaging · 2021Article
- Minor stroke with bilateral acute infarctions and combined vascular anomalies: A complex case report.Heliyon · 2020Article
- Differentiating High-Grade Gliomas from Brain Metastases at Magnetic Resonance: The Role of Texture Analysis of the Peritumoral Zone.Brain sciences · 2020Article
- CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression.Biology open · 2019Article
- Lack of choline elevation on proton magnetic resonance spectroscopy in grade I-III gliomas.The neuroradiology journal · 2019Article
- Article
- Role of Multivoxel Intermediate TE 2D CSI MR Spectroscopy and 2D Echoplanar Diffusion Imaging in Grading of Primary Glial Brain Tumours.Journal of clinical and diagnostic research : JCDR · 2017Article
- Novel application of chemical shift gradient echo in- and opposed-phase sequences in 3 T MRI for the detection of H-MRS visible lipids and grading of glioma.European radiology · 2016Article
- Multimodality Brain Tumor Imaging: MR Imaging, PET, and PET/MR Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Review
- Fast spectroscopic multiple analysis (FASMA) for brain tumor classification: a clinical decision support system utilizing multi-parametric 3T MR data.International journal of computer assisted radiology and surgery · 2015Article
- Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.PloS one · 2015Article
- Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques.World journal of radiology · 2014Review
- Automated differentiation of glioblastomas from intracranial metastases using 3T MR spectroscopic and perfusion data.International journal of computer assisted radiology and surgery · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the diagnostic value of 3T (1)H-MRS in grading cerebral gliomas using short and long echo times.
methods1H-MRS was performed on 71 patients with untreated cerebral gliomas. Metabolite ratios of NAA/Cr, Cho/Cr, Cho/NAA, and mI/Cr were calculated for short and long TE and compared between low and high grade gliomas. Lipids were qualitatively evaluated. ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades.
resultsIntratumoral Cho/Cr at both TEs and long TE Cho/NAA were significantly different between low and high grade gliomas. Peritumoral NAA/Cr of both TEs, as well as long TE Cho/Cr and Cho/NAA ratios, significantly differentiated the two tumor grades. Diagnostic sensitivity of peritumoral short TE NAA/Cr proved to be superior over the other metabolic ratios, whereas intratumoral short TE Cho/Cr reached the highest levels of specificity and accuracy. Overall, short TE 1H-MRS reached higher total sensitivity in predicting glioma grade, over long TE.
conclusionAn advantage was found in using short TE over long TE 1H-MRS in the discrimination of low versus high grade gliomas. Moreover, the results suggested that the peritumoral area of gliomas may be more valuable in predicting glioma grade than using only the intratumoral area.
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