ArticleContemporary clinical dentistry2012
Evaluation of interleukin -1B (+3954) gene polymorphism in patients with chronic and aggressive periodontitis: A genetic association study.
Article in Contemporary clinical dentistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis.Frontiers in immunology · 2021Pooled it
- Association between Interleukin-1β Gene -511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Polymorphic regions in the interleukin-1 gene and susceptibility to chronic periodontitis: a genetic association study.Genetic testing and molecular biomarkers · 2015Trial
- Association between Interleukin-1β Gene Polymorphism and Chronic Periodontitis.European journal of dentistry · 2021Article
- The Expression of Allele Changes in NLRP3 (rs35829419) and IL-1β (+3954) Gene Polymorphisms in Periodontitis and Coronary Artery Disease.Materials (Basel, Switzerland) · 2021Article
- IL-1B(3954) polymorphism and red complex bacteria increase IL-1β (GCF) levels in periodontitis.Journal of periodontal research · 2021Article
- Association of Interleukin-1β-31C/T, -511T/C and -3954C/T Single Nucleotide Polymorphism and Their Blood Plasma Level in Acquired Aplastic Anemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Detection of association between periodontitis and polymorphisms of IL-1β + 3954 and TNF-α -863 in the Korean population after controlling for confounding risk factors.Journal of periodontal research · 2020Article
- Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview.BMC oral health · 2019Review
- Interleukin-1β (3953/4) C→T polymorphism increases the risk of chronic periodontitis in Asians: evidence from a meta-analysis of 20 case-control studies.Archives of medical science : AMS · 2015Review
- Analysis of protein expression in periodontal pocket tissue: a preliminary study.Proteome science · 2015Article
- Interleukin-1β rs1143634 polymorphism and aggressive periodontitis susceptibility: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Uncovering the molecular networks in periodontitis.Proteomics. Clinical applications · 2014Review
- Interleukin 1β (+3954; -511) Genotype Polymorphism and its Association with Severe Chronic Generalized Periodontitis in the Malaysian Population.Contemporary clinical dentistryArticle
- Study of the association between the interleukin-1 β c.3954C>T polymorphism and periodontitis in a population sample from Bahia, Brazil.Contemporary clinical dentistryArticle
- Interleukin polymorphisms in aggressive periodontitis: A literature review.Journal of Indian Society of PeriodontologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIL-1 cytokines have central roles in the pathogenesis of periodontal disease. Polymorphism in the locus +3954 (C/T) of the human IL-1B gene has been shown to affect the levels of this cytokine.
aimThe aim of the present study was to investigate the association between the IL-1 B (+3954) gene polymorphism and the occurrence of different clinical forms of periodontitis. MATERIALS AND
methodsGenomic DNA was obtained from 90 individuals and amplified using the PCR with specific primers flanking the locus +3954 of IL-1B. PCR products were submitted to restriction endonuclease digestion and analyzed by gel electrophoresis, allowing for the determination of the genotypes and detection of the polymorphism. STATISTICAL ANALYSIS: Fisher's exact test was used for comparing the frequency of genotype distributions between groups.
resultsThe chronic periodontitis group displayed a higher percentage of T alleles (38%) when compared to the aggressive periodontitis group (20%) and to the control group (19%).
conclusionOur study data states that polymorphism in the locus +3954 of IL-1B gene could be a risk factor for chronic periodontitis in a sample of Indian population of Karnataka state.
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