ArticleGenome research2012
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Epigenome-Wide Association of Infant Feeding and Changes in DNA Methylation from Birth to 10 Years.Nutrients · 2020Trial
- Extended Lombardy's Neonatal Screening Dataset.Scientific data · 2025Article
- DNA methylation at birth and IgE trajectories from birth to adolescence, different patterns between White and Asian.Epigenomics · 2025Article
- Intergenerational association of DNA methylation between parents and offspring.Scientific reports · 2024Article
- Epigenetic Features in Newborns Associated with Preadolescence Lung Function and Asthma Acquisition during Adolescence.Epigenomes · 2024Article
- Polymorphisms in Glutathione S-Transferase (Genes · 2023Article
- Feasibility and ethics of using data from the Scottish newborn blood spot archive for research.Communications medicine · 2022Article
- Association of grandmaternal smoking during pregnancy with DNA methylation of grandchildren: the Isle of Wight study.Epigenomics · 2021Article
- Article
- DNA methylation profiles unique to Kalahari KhoeSan individuals.Epigenetics · 2021Article
- Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort.Environmental research · 2021Article
- Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC).International journal of epidemiology · 2020Article
- Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards.Epigenetics · 2020Article
- Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma.Epigenetics insights · 2020Article
- Assessment of dried blood spots for DNA methylation profiling.Wellcome open research · 2019Article
- The Role of Epigenetics in Type 1 Diabetes.Current diabetes reports · 2017Review
- DNA Methylome Profiling on the Infinium HumanMethylation450 Array from Limiting Quantities of Genomic DNA from a Single, Small Archived Bloodspot.Genetic testing and molecular biomarkers · 2017Article
- Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence.Vaccine · 2016Article
- Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies.American journal of epidemiology · 2016Article
- Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots.Clinical epigenetics · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
A major concern in common disease epigenomics is distinguishing causal from consequential epigenetic variation. One means of addressing this issue is to identify the temporal origins of epigenetic variants via longitudinal analyses. However, prospective birth-cohort studies are expensive and time consuming. Here, we report DNA methylomics of archived Guthrie cards for the retrospective longitudinal analyses of in-utero-derived DNA methylation variation. We first validate two methodologies for generating comprehensive DNA methylomes from Guthrie cards. Then, using an integrated epigenomic/genomic analysis of Guthrie cards and follow-up samplings, we identify interindividual DNA methylation variation that is present both at birth and 3 yr later. These findings suggest that disease-relevant epigenetic variation could be detected at birth, i.e., before overt clinical disease. Guthrie card methylomics offers a potentially powerful and cost-effective strategy for studying the dynamics of interindividual epigenomic variation in a range of common human diseases.
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Registered trials
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