ArticleCerebral cortex (New York, N.Y. : 1991)2013
Acute stress, but not corticosterone, disrupts short- and long-term synaptic plasticity in rat dorsal subiculum via glucocorticoid receptor activation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Midday and nadir salivary cortisol appear superior to cortisol awakening response in burnout assessment and monitoring.Scientific reports · 2018Trial
- Acute stress causes sex-specific changes to ventral subiculum synapses, circuitry, and anxiety-like behavior.Nature communications · 2025Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Transcriptional Profiling of Rat Prefrontal Cortex after Acute Inescapable Footshock Stress.Genes · 2023Article
- Stress-Induced Enhanced Long-Term Potentiation and Reduced Threshold for N-Methyl-D-Aspartate Receptor- and β-Adrenergic Receptor-Mediated Synaptic Plasticity in Rodent Ventral Subiculum.Frontiers in molecular neuroscience · 2021Article
- Stress gates an astrocytic energy reservoir to impair synaptic plasticity.Nature communications · 2020Article
- Genomic and epigenomic mechanisms of glucocorticoids in the brain.Nature reviews. Endocrinology · 2017Review
- Inoculation stress hypothesis of environmental enrichment.Neuroscience and biobehavioral reviews · 2015Review
- Stress facilitates late reversal learning using a touchscreen-based visual discrimination procedure in male Long Evans rats.Behavioural brain research · 2015Article
- Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis.Frontiers in cellular neuroscience · 2015Article
- Experience and the ever-changing brain: what the transcriptome can reveal.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Additive gene-environment effects on hippocampal structure in healthy humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inactivation of medial prefrontal cortex or acute stress impairs odor span in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Acute stress and hippocampal output: exploring dorsal CA1 and subicular synaptic plasticity simultaneously in anesthetized rats.Physiological reports · 2013Article
- Effects of acute restraint stress on set-shifting and reversal learning in male rats.Cognitive, affective & behavioral neuroscience · 2013Article
- The Protective Effects of Crocin on Input-Output Functions and Long-term Potentiation of Hippocampal CA1 Area in Rats Exposed to Chronic Social Isolated Stress.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The subiculum (SUB) serves as the major output structure of the hippocampus; therefore, exploring synaptic plasticity within this region is of great importance for understanding the dynamics of hippocampal circuitry and hippocampal-cortical interactions. Previous research has shown exposure to acute stress dramatically alters synaptic plasticity within the hippocampus proper. Using in vivo electrophysiological recordings in urethane-anesthetized adult male Sprague-Dawley rats, we tested the effects of either acute restraint stress (30 min) or corticosterone (CORT) injections (3 mg/kg; s.c.) on short- and long-term forms of synaptic plasticity in the Cornu Ammonis 1-SUB pathway. Paired-pulse facilitation and two forms of long-term plasticity (long-term potentiation and late-developing potentiation) were significantly reduced after exposure to acute stress but not CORT treatment. Measurements of plasma CORT confirmed similar levels of circulating hormone in animals exposed to either acute stress or CORT treatment. The disruptive effects of acute stress on both short- and long-term forms of synaptic plasticity are mediated by glucocorticoid receptor (GR) activation as these disruptions were blocked by pre-treatment with the selective GR antagonist RU38486 (10 mg/kg; s.c.). The present results highlight the susceptibility of subicular plasticity to acute stress and provide evidence that GR activation is necessary but not sufficient for mediating these alterations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.