ArticleCerebral cortex (New York, N.Y. : 1991)2013
Differential wiring of layer 2/3 neurons drives sparse and reliable firing during neocortical development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy.Stem cell research & therapy · 2025Article
- Modeling circuit mechanisms of opposing cortical responses to visual flow perturbations.PLoS computational biology · 2024Article
- FosGFP expression does not capture a sensory learning-related engram in superficial layers of mouse barrel cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Leveraging heterogeneity for neural computation with fading memory in layer 2/3 cortical microcircuits.PLoS computational biology · 2019Article
- Emergence of preconfigured and plastic time-compressed sequences in early postnatal development.Science (New York, N.Y.) · 2019Article
- Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking.Brain structure & function · 2018Article
- Structured networks support sparse traveling waves in rodent somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Neurogenesis during Abstinence Is Necessary for Context-Driven Methamphetamine-Related Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stimulation triggers endogenous activity patterns in cultured cortical networks.Scientific reports · 2017Article
- Arc expression identifies the lateral amygdala fear memory trace.Molecular psychiatry · 2016Article
- Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction.Brain research · 2015Review
- Structure of a single whisker representation in layer 2 of mouse somatosensory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A gradual depth-dependent change in connectivity features of supragranular pyramidal cells in rat barrel cortex.Brain structure & function · 2015Article
- Article
- Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex.Journal of neurophysiology · 2014Article
- Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D₃-MARRS.Scientific reports · 2013Article
- New technologies for examining the role of neuronal ensembles in drug addiction and fear.Nature reviews. Neuroscience · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Sensory information is transmitted with high fidelity across multiple synapses until it reaches the neocortex. There, individual neurons exhibit enormous variability in responses. The source of this diversity in output has been debated. Using transgenic mice expressing the green fluorescent protein coupled to the activity-dependent gene c-fos, we identified neurons with a history of elevated activity in vivo. Focusing on layer 4 to layer 2/3 connections, a site of strong excitatory drive at an initial stage of cortical processing, we find that fluorescently tagged neurons receive significantly greater excitatory and reduced inhibitory input compared with neighboring, unlabeled cells. Differential wiring of layer 2/3 neurons arises early in development and requires sensory input to be established. Stronger connection strength is not associated with evidence for recent synaptic plasticity, suggesting that these more active ensembles may not be generated over short time scales. Paired recordings show fosGFP+ neurons spike at lower stimulus thresholds than neighboring, fosGFP- neurons. These data indicate that differences in circuit construction can underlie response heterogeneity amongst neocortical neurons.
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