ReviewResults and problems in cell differentiation2012
Cell lineage allocation within the inner cell mass of the mouse blastocyst.
Review in Results and problems in cell differentiation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Experimentally unsupervised deconvolution for light-sheet microscopy with propagation-invariant beams.Light, science & applications · 2022Article
- Article
- Transition state dynamics during a stochastic fate choice.Development (Cambridge, England) · 2019Article
- Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling.Nature cell biology · 2019Article
- Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.Scientific reports · 2016Article
- Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity.Development (Cambridge, England) · 2015Article
- Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst.Cell reports · 2015Article
- The birth of embryonic pluripotency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst.PLoS genetics · 2014Article
- The WNT signaling antagonist Dickkopf-1 directs lineage commitment and promotes survival of the preimplantation embryo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception.TheScientificWorldJournal · 2014Review
- PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst.Stem cells (Dayton, Ohio) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
At the time of implantation, the early mouse embryo consists of three distinct cell lineages: the epiblast (EPI), primitive endoderm (PrE), and trophectoderm (TE). Here we will focus on the EPI and PrE cell lineages, which arise within the inner cell mass (ICM) of the blastocyst. Though still poorly understood, our current understanding of the mechanisms underlying this lineage allocation will be discussed. It was originally thought that lineage choice was strictly controlled by the position of a cell within the ICM. However, it is now believed that the EPI and PrE lineages are defined both by their position and by the expression of lineage-specific transcription factors. Interestingly, these lineage-specific transcription factors are initially co-expressed in early ICM cells, suggesting an initial multi-lineage priming state. Thereafter, lineage-specific transcription factors display a mutually exclusive salt-and-pepper distribution that reflects cell specification of the EPI or PrE fates. Later on, lineage segregation and likely commitment are completed with the sequestration of PrE cells to the surface of the ICM, which lies at the blastocyst cavity roof. We discuss recent advances that have focused on elucidating how the salt-and-pepper pattern is established and then resolved within the ICM, leading to the correct apposition of cell lineages in preparation for implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.