ReviewDigestive diseases and sciences2013
Stimulation of calcitonin gene-related peptide release through targeting capsaicin receptor: a potential strategy for gastric mucosal protection.
Review in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Mechanism of Weiwei granules in the treatment of chronic activeHistology and histopathology · 2024Trial
- A comprehensive review on calcitonin gene-related peptide in the management of gastrointestinal disorders.Inflammopharmacology · 2025Review
- Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology.Frontiers in pharmacology · 2025Review
- Organization and morphology of calcitonin gene-related peptide-immunoreactive axons in the whole mouse stomach.The Journal of comparative neurology · 2023Article
- Therapeutic peptides: current applications and future directions.Signal transduction and targeted therapy · 2022Review
- Effects of the diphenylheptane extract ofIranian journal of basic medical sciences · 2021Article
- Physiological function and molecular composition of ATP-sensitive KJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Article
- Effect of ropivacaine on peripheral neuropathy in streptozocin diabetes-induced rats through TRPV1-CGRP pathway.Bioscience reports · 2019Article
- Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart.Current cardiology reviews · 2019Review
- Alterations in Gastric Mucosal Expression of Calcitonin Gene-Related Peptides, Vanilloid Receptors, and Heme Oxygenase-1 Mediate Gastroprotective Action of Carbon Monoxide against Ethanol-Induced Gastric Mucosal Lesions.International journal of molecular sciences · 2018Article
- Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats.Pharmaceutical biology · 2017Article
- Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators.World journal of gastroenterology · 2016Article
- Gut-Brain Axis in Gastric Mucosal Damage and Protection.Current neuropharmacology · 2016Review
- Activity of alkaloids on peptic ulcer: what's new?Molecules (Basel, Switzerland) · 2015Review
- Geraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcitonin gene-related peptide (CGRP) is a predominant neurotransmitter from capsaicin-sensitive sensory nerves, which are widely distributed in the gastrointestinal system. These sensory nerves are reported to be involved in the protection of gastric mucosa against damage by various stimuli, and CGRP is a potential mediator in this process. In addition to increase in gastric mucosal blood flow, the beneficial effects of CGRP on gastric mucosa include inhibition of gastric acid secretion, prevention of cellular apoptosis and oxidative injury. The synthesis and release of CGRP is regulated by the capsaicin receptor which is known as transient receptor potential vanilloid subfamily member 1 (TRPV1) and the agonists of TRPV1 have the potential for gastric mucosal protection. So far, multiple TRPV1 agonists, including capsaicin, capsiate, anandamide and rutaecarpine are reported to exert beneficial effects on gastric mucosal injury induced by various stimuli. Therefore, the TRPV1/CGRP pathway represents a novel target for therapeutic intervention in human gastric mucosal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.