ArticleThe international journal of cardiovascular imaging2013
Impact of acute normobaric hypoxia on regional and global myocardial function: a speckle tracking echocardiography study.
Article in The international journal of cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Moderate Normobaric Hypoxia Does Not Exacerbate Left Ventricular Dysfunction After Exhaustive Exercise in Athletes and Untrained Individuals.Journal of clinical medicine · 2025Article
- Effects of Normobaric Hypoxia and Adrenergic Blockade over 72 h on Cardiac Function in Rats.International journal of molecular sciences · 2023Article
- A change of heart: Mechanisms of cardiac adaptation to acute and chronic hypoxia.The Journal of physiology · 2022Article
- Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males.International journal of environmental research and public health · 2022Article
- A randomized controlled trial of enhancing hypoxia-mediated right cardiac mechanics and reducing afterload after high intensity interval training in sedentary men.Scientific reports · 2021Article
- Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia.Frontiers in physiology · 2021Article
- Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Effects of Adrenergic Agonists and Antagonists on Cardiopulmonary Function During Normobaric Hypoxia in Rat.Frontiers in physiology · 2019Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of this study was to evaluate the influence of normobaric hypoxia on myocardial function in healthy humans. Fourteen subjects underwent two-dimensional speckle tracking echocardiography (2D-STE) examination during normoxia and in a normobaric hypoxia chamber. Examinations were performed at rest and during bicycle exercise test. The following parameters were quantified in both atria and ventricles by 2D-STE: Global Strain (S), systolic strain rate (SRS), early (SRE) and late (SRA) diastolic strain rate. During hypoxia SRS and SRE increased significantly in both ventricles compared to baseline. The increase of LV SRS and SRE during normoxic exercise was significantly higher when compared with exercise under hypoxia (for SRS -0.55 ± 0.22 vs. -0.34 ± 0.24 1/s, p = 0.024; for SRE 0.56 ± 0.29 vs. 0.23 ± 0.29 1/s, p = 0.005). For the right ventricle (RV) no significant difference of exercise induced increase of systolic contractility was found (SRS -1.07 ± 0.53 under normoxia vs. -1.28 ± 0.24 1/s under hypoxic conditions, p = 0.47). A shift from passive conduit (SRE) to active contraction (SRA) phase during hypoxia was noted for the right atrium (RA) (SRE/SRA 0.72 ± 0.13 under hypoxia vs. 1.17 ± 0.17 under normoxia). The ratio SRE/SRA of RA was closely related to pulmonary systolic pressure (r = -0.78, p < 0.001). Exposure to normobaric hypoxia leads to an increase of regional myocardial deformation in both ventricles. The contractile reserve during hypoxic exercise is reduced in LV, whereas RV systolic deformation rate is maintained. In addition, hypoxia had an impact on the ratio of passive conduit to active contraction phase in right atrium.
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