ArticlePsychopharmacology2013
Working memory in the odor span task: effects of chlordiazepoxide, dizocilpine (MK801), morphine, and scopolamine.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist.Psychopharmacology · 2023Review
- Generalized, cross-modal, and incrementing non-matching-to-sample in rats.Learning & behavior · 2023Article
- Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species.Current topics in behavioral neurosciences · 2023Review
- Incrementing non-matching- but not matching-to-sample is rapidly learned in an automated version of the odor span task.Animal cognition · 2022Article
- Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a DPsychopharmacology · 2021Article
- A novel paradigm for assessing olfactory working memory capacity in mice.Translational psychiatry · 2020Article
- Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task.Psychopharmacology · 2020Article
- Effects of NMDA antagonist dizocilpine (MK-801) are modulated by the number of distractor stimuli in the rodent odor span task of working memory.Neurobiology of learning and memory · 2019Article
- Effects of N-Methyl-D-aspartate (NMDA) antagonists ketamine, methoxetamine, and phencyclidine on the odor span test of working memory in rats.Experimental and clinical psychopharmacology · 2018Article
- Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine.Neurobiology of learning and memory · 2017Article
- Validation of the human odor span task: effects of nicotine.Psychopharmacology · 2017Article
- Interactions between medial prefrontal cortex and dorsomedial striatum are necessary for odor span capacity in rats: role of GluN2B-containing NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Medial prefrontal cortex and dorsomedial striatum are necessary for the trial-unique, delayed nonmatching-to-location (TUNL) task in rats: role of NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Behavioral pharmacology of the odor span task: Effects of flunitrazepam, ketamine, methamphetamine and methylphenidate.Journal of the experimental analysis of behavior · 2016Article
- Olfactory Stimulus Control and the Behavioral Pharmacology of Remembering.Behavior analysis (Washington, D.C.) · 2016Article
- Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Effect of morphine on the persistence of long-term memory in rats.Psychopharmacology · 2015Article
- Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis.Frontiers in behavioral neuroscience · 2015Article
- Effects of MDMA on olfactory memory and reversal learning in rats.Neurobiology of learning and memory · 2014Article
- What-Where-When Memory in the Rodent Odor Span Task.Learning and motivation · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleA number of tasks are used to assess working memory in rodents, but the odor span task (OST) is unique in studying performance as a function of the number of stimuli to remember.
objectivesThe purpose of the present study was to better characterize the behavioral pharmacology of the OST by exploring the effects of several amnestic agents including an NMDA antagonist (dizocilpine), a positive GABA-A modulator (chlordiazepoxide), an anticholinergic compound (scopolamine), and as a negative control, an opiate receptor agonist (morphine).
methodsRats were trained to perform on the OST which is a non-match-to-sample procedure with an incrementing number of sample odors to remember as the session progresses. Trials with a simple odor discrimination task (SD) were interspersed to provide a control for effects unrelated to memory load.
resultsAll four drugs disrupted performances on the OST task in a dose-dependent fashion, but only the NMDA antagonist dizocilpine produced impairments that were clearly dependent on the number of stimuli to remember. Dizocilpine impaired OST performance at a dose (0.1 mg/kg) that did not affect SD, and that impairment depended on memory load. Chlordiazepoxide (3.0 mg/kg) also produced amnestic effects that were manifest by shorter memory spans and runs of correct responding. In contrast, morphine and scopolamine impaired OST accuracy only at doses that also disrupted SD (18.0 and 0.3 mg/kg, respectively).
conclusionsThese results provide evidence of NMDA and benzodiazepine modulation of working memory as assessed by the OST.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.