ArticleCell cycle (Georgetown, Tex.)2012
4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.Molecular biology reports · 2023Article
- Multiple Roles of PLK1 in Mitosis and Meiosis.Cells · 2023Review
- Identification of a centrosome-related prognostic signature for breast cancer.Frontiers in oncology · 2023Article
- The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts.BMC molecular and cell biology · 2020Article
- Cyclin-dependent kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis-G1 transition.FEBS letters · 2020Article
- Article
- Co-targeting PLK1 and mTOR induces synergistic inhibitory effects against esophageal squamous cell carcinoma.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Meeting the meiotic challenge: Specializations in mammalian oocyte spindle formation.Molecular reproduction and development · 2018Review
- PLK1 regulates spindle association of phosphorylated eukaryotic translation initiation factor 4E-binding protein and spindle function in mouse oocytes.American journal of physiology. Cell physiology · 2017Article
- Regulation of 4E-BP1 activity in the mammalian oocyte.Cell cycle (Georgetown, Tex.) · 2017Article
- The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.Scientific reports · 2017Article
- Translation regulator ballet in meiotic spindle.Cell cycle (Georgetown, Tex.) · 2017Article
- A researcher's guide to the galaxy of IRESs.Cellular and molecular life sciences : CMLS · 2017Review
- PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients.Journal of experimental & clinical cancer research : CR · 2017Article
- Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation.International journal of medical sciences · 2017Article
- Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications.Molecular and cellular biology · 2016Review
- PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability.Oncotarget · 2015Article
- CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essential function of eIF4E-binding protein 1 (4E-BP1) in translation initiation has been well established; however, the role of 4E-BP1 in normal cell cycle progression is coming to attention. Here, we revealed the role of 4E-BP1 on mitotic regulation and chromosomal DNA dynamics during mitosis. First, we have observed the co-localization of the phosphorylated 4E-BP1 at T37/46 with Polo-like kinase 1 (PLK1) at the centrosomes during. Depression of 4E-BP1 by small interfering RNA in HepG2 or HeLa cells resulted in an increased outcome of polyploidy and aberrant mitosis, including chromosomal DNA misaligned and multi-polar spindles or multiple centrosomes. We observed that 4E-BP1 interacted with PLK1 directly in vitro and in vivo in mitotic cells, and the C-terminal aa 77-118 of 4E-BP1 mediates its interaction with PLK1. PLK1 can phosphorylate 4E-BP1 in vitro. Furthermore, the depletion of 4E-BP1 sensitized HepG2 and HeLa cells to the microtubule disruption agent paclitaxel. These results demonstrate that 4E-BP1, beyond its role in translation regulation, can function as a regulator of mitosis via interacting with PLK1, and possibly plays a role in genomic stability maintaining.
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