ArticleDisease models & mechanisms2013
Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses.
Article in Disease models & mechanisms, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study.Alimentary pharmacology & therapeutics · 2014Trial
- A review on current advancement in zebrafish models to study chronic inflammatory diseases and their therapeutic targets.Heliyon · 2024Review
- Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease.International journal of molecular sciences · 2023Review
- Systematic Characterization of the Disruption of Intestine during Liver Tumor Progression in theCells · 2022Article
- Current Methods to Investigate Nociception and Pain in Zebrafish.Frontiers in neuroscience · 2021Review
- Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs.Frontiers in cell and developmental biology · 2020Review
- Epithelial delamination is protective during pharmaceutical-induced enteropathy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Vital Dye CDr10b Labels the Zebrafish Mid-Intestine and Lumen.Molecules (Basel, Switzerland) · 2017Article
- Application of Zebrafish Models in Inflammatory Bowel Disease.Frontiers in immunology · 2017Review
- Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies.Disease models & mechanisms · 2016Article
- A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Inflammatory diseases modelling in zebrafish.World journal of experimental medicine · 2016Article
- Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation.Current pathobiology reports · 2015Article
- Epigenetic control of intestinal barrier function and inflammation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish.Scientific reports · 2014Article
- The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications.Journal of gastroenterology · 2014Review
- Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish.Inflammatory bowel diseases · 2014Review
- Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish.Disease models & mechanisms · 2014Article
- Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Beside their analgesic properties, opiates exert beneficial effects on the intestinal wound healing response. In this study, we investigated the role of μ-opioid receptor (MOR) signaling on the unfolded protein response (UPR) using a novel zebrafish model of NSAID-induced intestinal injury. The NSAID glafenine was administered to zebrafish larvae at 5 days post-fertilization (dpf) for up to 24 hours in the presence or absence of the MOR-specific agonist DALDA. By analysis with histology, transmission electron microscopy and vital dye staining, glafenine-treated zebrafish showed evidence of endoplasmic reticulum and mitochondrial stress, with disrupted intestinal architecture and halted cell stress responses, alongside accumulation of apoptotic intestinal epithelial cells in the lumen. Although the early UPR marker BiP was induced with glafenine-induced injury, downstream atf6 and s-xbp1 expression were paradoxically not increased, explaining the halted cell stress responses. The μ-opioid agonist DALDA protected against glafenine-induced injury through induction of atf6-dependent UPR. Our findings show that DALDA prevents glafenine-induced epithelial damage through induction of effective UPR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.