Evidence map›Paper›PMID 22917779›Full record

ReviewAdvanced drug delivery reviews2012

Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine.

Xue-Qing Zhang, Xiaoyang Xu, Nicolas Bertrand, Eric Pridgen, Archana Swami, Omid C Farokhzad

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. Review
  3. Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Development, characterization, andInternational journal of pharmaceutics: X · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xue-Qing ZhangLaboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
Xiaoyang Xu
Nicolas Bertrand
Eric Pridgen
Archana Swami
Omid C Farokhzad

Funding

The Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MESIROV, JILL P. · 2010 to 2014
$11.3M
Sensitize Chemoresistant Breast Cancer by Nano-delivery of siRNA and CisplatinF32CA168163 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI XU, XIAOYANG · 2012 to 2014
$151k
CIHRNCI NIH HHS 1F32CA168163-01NCI NIH HHS CA151884NCI NIH HHS F32 CA168163NCI NIH HHS U54 CA151884NHLBI NIH HHS HHSN268201000045C
6 · The paper itself

Abstract

The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to design flexibility, small sizes, large surface-to-volume ratio, and ease of surface modification with multivalent ligands to increase avidity for target molecules. Nanomaterials can be engineered to interact with specific biological components, allowing them to benefit from the insights provided by personalized medicine techniques. To tailor these interactions, a comprehensive knowledge of how nanomaterials interact with biological systems is critical. Herein, we discuss how the interactions of nanomaterials with biological systems can guide their design for diagnostic, imaging and drug delivery purposes. A general overview of nanomaterials under investigation is provided with an emphasis on systems that have reached clinical trials. Finally, considerations for the development of personalized nanomedicines are summarized such as the potential toxicity, scientific and technical challenges in fabricating them, and regulatory and ethical issues raised by the utilization of nanomaterials.

Indexed as

NanomedicinePrecision MedicineAnimalsHumansLigandsNanostructuresProtein BindingLigands

Identifiers

PMID22917779
PMCPMC3517211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.