ArticleJournal of neurology, neurosurgery, and psychiatry2012
Differential susceptibility to motor impulsivity among functional subtypes of Parkinson's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes.medRxiv : the preprint server for health sciences · 2026Article
- Motor planning stage of gait initiation: effects of aging, Parkinson's disease, and associations with cognitive function.Experimental brain research · 2025Article
- Article
- Cognitive Function and Postural Control Strategies in Relation to Disease Progression in Patients with Parkinson's Disease.International journal of environmental research and public health · 2022Article
- Development and Validation of a Fall Questionnaire for Patients with Parkinson's Disease.Movement disorders clinical practice · 2022Article
- Altered Brain Functional Network in Subtypes of Parkinson's Disease: A Dynamic Perspective.Frontiers in aging neuroscience · 2021Article
- Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype.Brain : a journal of neurology · 2020Article
- Postural Instability in Parkinson's Disease: A Review.Brain sciences · 2019Review
- Self-reported and experimentally induced self-disgust is heightened in Parkinson's disease: Contribution of behavioural symptoms.PloS one · 2019Article
- Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease.Brain and behavior · 2018Article
- Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses.Neuropsychologia · 2017Article
- Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson's Disease.Frontiers in human neuroscience · 2017Article
- Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype.Annals of clinical and translational neurology · 2017Article
- Cognitive function and other non-motor features in non-demented Parkinson's disease motor subtypes.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Identifying the Basal Ganglia network model markers for medication-induced impulsivity in Parkinson's disease patients.PloS one · 2015Article
- Effects of combined MAO-B inhibitors and levodopa vs. monotherapy in Parkinson's disease.Frontiers in aging neuroscience · 2014Article
- Article
- The effect of Parkinson's disease subgroups on verbal and nonverbal fluency.Journal of clinical and experimental neuropsychology · 2014Article
- Inhibition, executive function, and freezing of gait.Journal of Parkinson's disease · 2014Article
- Impulsive and compulsive behaviors in Parkinson's disease.Annual review of clinical psychology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesParkinson's disease patients with predominant postural instability and gait difficulties (PIGD) may experience unique cognitive difficulties compared to patients with tremor predominant (TD) symptoms. PIGD patients are also at high risk for falling, and some of the worst fallers seem to react impulsively to their environment. We tested the hypothesis that PIGD patients show poorer control over motor impulses compared to TD patients.
methods34 PD participants were divided into predominant PIGD (n=17) or TD (n=17) functional subtypes based on their presenting symptoms in their optimally treated motor state. All participants performed a speeded reaction task that quantified motor impulsivity and the proficiency of inhibiting prepotent motor impulses.
resultsThe groups showed similar reaction times, but compared to TD patients, PIGD patients made significantly more impulsive motor errors. Notably, when the initial impulsive erroneous response was avoided, PIGD and TD groups were similar in their ability to suppress the incorrect motor impulse from further interfering with the selection of a correct action.
conclusionsPD patients with PIGD predominant symptoms show greater susceptibility to acting on prepotent motor impulses compared to TD patients. This finding may have direct implications for fall risk and also points to dissociable neurocognitive pathologies in TD and PIGD subtypes. Clinically, the use of specific cognitive instruments to assess the expression and inhibition of motor impulses may help identify PD patients who have difficulty 'thinking before they leap' and are at high risk of falling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.