Trial reportContemporary clinical trials2012
Efficacy and effectiveness as aspects of cluster randomized trials with nursing home residents: methodological insights from a pneumonia prevention trial.
Trial report in Contemporary clinical trials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Oral care measures for preventing nursing home-acquired pneumonia.The Cochrane database of systematic reviews · 2022Pooled it
- Setting Priorities to Inform Assessment of Care Homes' Readiness to Participate in Healthcare Innovation: A Systematic Mapping Review and Consensus Process.International journal of environmental research and public health · 2020Pooled it
- Challenges of conducting research in long-term care facilities: a systematic review.BMC geriatrics · 2018Pooled it
- Oral care measures for preventing nursing home-acquired pneumonia.The Cochrane database of systematic reviews · 2018Pooled it
- Iowa nursing facility oral hygiene (INFOH) intervention: A clinical and microbiological pilot randomized trial.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2018Trial
- Pain Management Algorithms for Implementing Best Practices in Nursing Homes: Results of a Randomized Controlled Trial.Journal of the American Medical Directors Association · 2016Trial
- Maturation of the MOUTh Intervention: From Reducing Threat to Relationship-Centered Care.Journal of gerontological nursing · 2016Trial
- A cluster-randomized controlled trial of a multicomponent intervention protocol for pneumonia prevention among nursing home elders.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Trial
- The effectiveness of a desensitization technique for mitigating oral and facial tactile hypersensitivity in institutionalized older persons: A randomized controlled trial.Journal of dental sciences · 2021Article
- Mouth Care in Assisted Living: Potential Areas for Improvement.Journal of the American Medical Directors Association · 2021Article
- Correlation of GSTM1 gene deletion in joint synovial fluid with the recovery of patients undergoing artificial hip replacement.Experimental and therapeutic medicine · 2018Article
- Nursing interventions in adult patients with oropharyngeal dysphagia: a systematic review.European geriatric medicine · 2018Review
- Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship: Randomized Controlled Trials.Infection control and hospital epidemiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This report discusses how methodological aspects of study efficacy and effectiveness combine in cluster randomized trials in nursing homes. Discussion focuses on the relationships between these study aspects in the Pneumonia Reduction in Institutionalized Disabled Elders (PRIDE) trial, an ongoing cluster randomized clinical trial of pneumonia prevention among nursing home residents launched in October 2009 in Greater New Haven, Connecticut. This clinical trial has enrolled long-term care nursing home residents, over 65years in age, who have either inadequate oral care or swallowing difficulty, previously identified risk factors for pneumonia. It has used a multicomponent intervention consisting of manual tooth/gum brushing, 0.12% chlorhexidine oral rinse administered twice daily by nurses, and upright feeding positioning at meals to reduce rates of radiographically documented pneumonia. Cluster randomization is attractive for nursing home intervention studies because physical proximity and administrative arrangements make it difficult to deliver different interventions to residents of the same nursing home. Implementing an intervention in an entire home requires integration into the daily life of residents and into the administrative procedures of the nursing home. This characteristic of nursing home cluster randomized trials makes them approximate "real-world" research contexts, but implementation can be challenging. The PRIDE trial of pneumonia prevention utilized specific methodological choices that include both efficacy and effectiveness elements. Cluster randomized trials in nursing homes having elements of both efficacy and effectiveness (i.e., hybrid designs) can address some of the methodological challenges of conducting clinical research in nursing homes; they have distinctive advantages and some limitations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.