ArticleBMC musculoskeletal disorders2012
Is knee osteoarthritis a symmetrical disease? Analysis of a 12 year prospective cohort study.
Article in BMC musculoskeletal disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06717529 (Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis), which is not on this map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis
Who cites it
71 citing papers in PubMed.
- Article
- Asymmetrical biomechanics in knee osteoarthritis: a review of contralateral risk from primary disease to post-arthroplasty progression.EFORT open reviews · 2026Review
- Clinical and Nonclinical Determinants of Simultaneous vs Staged Bilateral Total Knee Arthroplasty.Arthroplasty today · 2026Article
- Bidirectional longitudinal relationships between MRI-detected structural changes and contralateral knee pain in knee osteoarthritis: Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage open · 2026Article
- Multimodal model integrating ultrasound and demographic data for the diagnosis of knee osteoarthritis.BMC medical imaging · 2026Article
- A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individuals.medRxiv : the preprint server for health sciences · 2026Article
- Reduction in complication rate and hospital length of stay following robotic arm-assisted simultaneous bilateral total knee arthroplasty when compared to conventional techniques: a cohort study with minimum one year follow-up.Journal of robotic surgery · 2026Article
- Neuromuscular and Kinematic Strategies During Step-Up and Down-Forwards Task in Individuals with Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Relation of vertical ground reaction forces while walking to contralateral structural worsening in adults with unilateral knee osteoarthritis: the Multicenter Osteoarthritis Study.Clinical biomechanics (Bristol, Avon) · 2026Article
- Novel Nerve-Selective Treatment for Managing Knee Pain from Symptomatic Osteoarthritis: A Preliminary Case Series.International medical case reports journal · 2026Article
- Lectin Microarray-based Glycomics and Machine Learning Identify Shared Osteoarthritis Biomarkers in Humans, Dogs, and Horses.bioRxiv : the preprint server for biology · 2025Article
- Clinical safety and efficacy of simultaneous bilateral total knee arthroplasty in an Asian population: a propensity score-matched analysis.Journal of orthopaedic surgery and research · 2025Article
- Evaluation of an automated laminar cartilage T2 relaxation time analysis method in an early osteoarthritis model.Skeletal radiology · 2025Observational
- Gait Asymmetry and Post-Traumatic Osteoarthritis Following Anterior Cruciate Ligament Rupture: A Preliminary Study.Biology · 2025Article
- Methodology Development for Investigating Pathophysiological [Biomedicines · 2025Article
- Postoperative Pain and Opiate Requirement is Increased Following Second-Side Surgery Among Patients Undergoing Staged Total Knee Arthroplasty.Arthroplasty today · 2025Article
- Simultaneous vs Staged Procedures for Bilateral Total Knee Arthroplasty: Reduced Infection, Cost, and Readmission Rates Associated With Simultaneous Procedures.Arthroplasty today · 2025Article
- Comparison of quadriceps femoris properties, surface electromyography parameters and foot posture asymmetries between patients with unilateral and bilateral knee osteoarthritis.Frontiers in physiology · 2025Article
- Comparative study of simultaneous and staged bilateral total knee arthroplasty: is age a key factor in surgical outcomes?BMC musculoskeletal disorders · 2024Article
- Comparison of the asymmetries in foot posture, gait and plantar pressure between patients with unilateral and bilateral knee osteoarthritis based on a cross-sectional study.Scientific reports · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to document the development of bilateral knee osteoarthritis over a 12 year period using a middle-aged population-based cohort with knee pain at inclusion.
methodsOne hundred and forty three patients aged 35 to 54 were recruited from a population based cohort of 279 subjects who had knee pain at baseline and assessed with clinical and radiographic data, with 5 and 12 year follow up. The data was analysed with regard to the development and progression of uni- and bilateral knee osteoarthritis over 12 years. A definition of KL = 1 was used to define radiographic disease.
results24 of the 30 (80%) patients with unilateral disease at baseline developed bilateral disease after 12 years. At baseline 37 patients (26%) had bilateral disease, whereas that number increased to 65 (52%) at 5 years and 100 (70%) at the 12 year follow up. The most common pattern was medial compartment involvement in both knees. Six patients had lateral compartment disease in one knee and medial in the other whereas only two had lateral compartment disease bilaterally.
conclusionsBilateral knee osteoarthritis is very common with time, as the majority of sufferers will eventually develop radiographic disease in both knees. Clinicians need to be aware of the 'joint at risk' and researchers need to remember to account for both knees when assessing the relationship between physical function, pain and structural disease. The other knee should not be used for comparison, even if it appears to be normal at baseline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.