ArticleAntimicrobial agents and chemotherapy1990
Potentiation of chloroquine activity against Plasmodium falciparum by the peroxidase-hydrogen peroxide system.
Article in Antimicrobial agents and chemotherapy, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases.Scientific reports · 2019Article
- Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum.International journal for parasitology. Drugs and drug resistance · 2017Article
- Oxidative stress in malaria.International journal of molecular sciences · 2012Review
- Degrees of chloroquine resistance in Plasmodium - is the redox system involved?International journal for parasitology. Drugs and drug resistance · 2012Article
- Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials.The Biochemical journal · 1999Article
- Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil functions in vitro.Antimicrobial agents and chemotherapy · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we examined the potential interactions between antimalarial (chloroquine, quinine, and mefloquine) and oxidant reagents. The data indicate that their effects enhance those of one another in vitro. The viability of Plasmodium falciparum in culture was assessed by [3H]hypoxanthine incorporation during 24 h of incubation in the presence of lactoperoxidase, glucose-glucose oxidase, hydrogen peroxide, chloroquine, quinine, and mefloquine, either alone or in combination. At subinhibitory concentrations, a significant inhibition was produced by the following combinations: lactoperoxidase plus hydrogen peroxide, lactoperoxidase plus glucose-glucose oxidase, lactoperoxidase plus hydrogen peroxide or glucose-glucose oxidase plus chloroquine or quinine but not with mefloquine. Deletion of any component from the system markedly decreased the toxic effect on P. falciparum. This toxic effect was not inhibited by catalase. These results indicate that the peroxidase-hydrogen peroxide system and antimalarial drugs can potentiate each other to inhibit the growth of P. falciparum.
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Registered trials
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