ArticlePloS one2012
The retrograde frequency response of passive dendritic trees constrains the nonlinear firing behaviour of a reduced neuron model.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Effective Stimulation Type and Waveform for Force Control of the Motor Unit System: Implications for Intraspinal Microstimulation.Frontiers in neuroscience · 2021Article
- PyMUS: Python-Based Simulation Software for Virtual Experiments on Motor Unit System.Frontiers in neuroinformatics · 2018Article
- Synaptic control of the shape of the motoneuron pool input-output function.Journal of neurophysiology · 2017Article
- Development of modified cable models to simulate accurate neuronal active behaviors.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.PloS one · 2014Article
- Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite.Frontiers in computational neuroscience · 2014Article
- Article
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2 authors.
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Abstract
Our goal was to investigate how the propagation of alternating signals (i.e. AC), like action potentials, into the dendrites influenced nonlinear firing behaviour of motor neurons using a systematically reduced neuron model. A recently developed reduced modeling approach using only steady-current (i.e. DC) signaling was analytically expanded to retain features of the frequency-response analysis carried out in multicompartment anatomically reconstructed models. Bifurcation analysis of the extended model showed that the typically overlooked parameter of AC amplitude attenuation was positively correlated with the current threshold for the activation of a plateau potential in the dendrite. Within the multiparameter space map of the reduced model the region demonstrating "fully-bistable" firing was bounded by directional DC attenuation values that were negatively correlated to AC attenuation. Based on these results we conclude that analytically derived reduced models of dendritic trees should be fit on DC and AC signaling, as both are important biophysical parameters governing the nonlinear firing behaviour of motor neurons.
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