ArticlePloS one2012
Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- The HOXA gene cluster: a critical regulator in bone-related disorders.Annals of medicine · 2026Review
- Pelvic Girdle Fluctuating Asymmetry in the Domestic Cat (Animals : an open access journal from MDPI · 2026Article
- Multiple gene knockouts in newts reveal novel functions of 5' Hox genes in limb development along the anterior-posterior and proximal-distal axes.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Molecular insight into transcriptome profiling of aerobic exercise induced changes in aged skeletal muscle.npj aging · 2026Article
- The role of the PTHrP/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data.Animals : an open access journal from MDPI · 2023Article
- Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos.Cell & bioscience · 2023Article
- HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.Frontiers in cell and developmental biology · 2022Review
- Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation.Frontiers in cell and developmental biology · 2022Article
- Stimulation of the Runx2 P1 promoter by collagen-derived dipeptide prolyl-hydroxyproline bound to Foxg1 and Foxo1 in osteoblasts.Bioscience reports · 2021Article
- The Embryological Landscape of Mayer-Rokitansky-Kuster-Hauser Syndrome: Genetics and Environmental Factors.The Yale journal of biology and medicine · 2021Review
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- Molecular fingerprint of female bovine embryos produced in vitro with high competence to establish and maintain pregnancy†.Biology of reproduction · 2020Article
- lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration.Stem cell research & therapy · 2019Review
- Bone morphology is regulated modularly by global and regional genetic programs.Development (Cambridge, England) · 2019Article
- Hoxa13 regulates expression of common Hox target genes involved in cartilage development to coordinate the expansion of the autopodal anlage.Development, growth & differentiation · 2019Article
- Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones.PloS one · 2019Article
- Hox11 Function Is Required for Region-Specific Fracture Repair.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Epigenetic inactivation of HOXA11, a novel functional tumor suppressor for renal cell carcinoma, is associated with RCC TNM classification.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During limb development, posterior Hox genes of the Hoxa- and Hoxd cluster provide positional information along the limb axis. Here we report a new function for Hoxa11 and Hoxd11 in regulating the early steps of chondrocyte differentiation. We analyzed forelimbs of Hoxa11(-/-);d11(-/-) and Ulnaless mice, which are characterized by specifically shortened zeugopods. By detailed morphological and molecular analyses, we show that loss of Hoxa11 and Hoxd11 in the ulna of both mutants leads to an arrest of chondrocyte differentiation at a step before the separation into round and columnar cells takes place. Furthermore, we demonstrate that Hoxa11 and Hoxd11 act upstream of Runx2 and Shox2, two key regulators of chondrocyte differentiation. We hypothesize that Runx2 activates Shox2 in early chondrocytes, which at later stages induces Runx2 expression to regulate hypertrophic differentiation. These results give insight into mechanisms by which positional information might be translated into a specific bone pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.