ArticlePloS one2012
Placental transfer of maternally-derived IgA precludes the use of guthrie card eluates as a screening tool for primary immunodeficiency diseases.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Farm exposure in infancy is associated with elevated systemic IgGScience translational medicine · 2025Article
- Analysis of the immune response using FTIR spectroscopy in mothers and their newborns with different vaccination schemes for COVID-19.Scientific reports · 2024Article
- Linear Immunoglobulin a Bullous Dermatosis in Children.Frontiers in pediatrics · 2022Review
- Dried blood sample analysis by antibody array across the total testing process.Scientific reports · 2021Article
- Innate Mechanisms in Selective IgA Deficiency.Frontiers in immunology · 2021Review
- HLA antibody repertoire in infants suggests selectivity in transplacental crossing.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- Article
- Article
- Low T Cell Numbers Resembling T-B+ SCID in a Patient with Wiskott-Aldrich Syndrome and the Outcome of Two Hematopoietic Stem Cell Transplantations.Journal of clinical immunology · 2017Article
- A Novel Targeted Screening Tool for Hypogammaglobulinemia: Measurement of Serum Immunoglobulin (IgG, IgM, IgA) Levels from Dried Blood Spots (Ig-DBS Assay).Journal of clinical immunology · 2015Article
- Protein identification from dried nipple aspirate fluid on Guthrie cards using mass spectrometry.Molecular medicine reports · 2015Article
- Vaccines against enteric infections for the developing world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Calculated globulin (CG) as a screening test for antibody deficiency.Clinical and experimental immunology · 2014Article
- Detection of immunoglobulin isotypes from dried blood spots.Journal of immunological methods · 2014Article
- Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: a multicenter study in Argentina.Journal of clinical immunology · 2013Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a need for neonatal screening tools to improve the long-term clinical outcome of patients with primary immunodeficiency diseases (PID). Recently, a PCR-based screening method for both TRECs and KRECs using Guthrie card samples has been developed. However, the applicability of these excision circle assays is limited to patients with severe T or B cell lymphopenia (SCID, XLA and A-T), whereas the most common forms of PID are not detected. Absence of serum IgA is seen in a major fraction of patients with immunological defects. As serum IgA in newborns is considered to be of fetal origin, eluates from routinely collected dried blood spot samples might thus be suitable for identification of children with PID. To assess the applicability of such screening assays, stored Guthrie card samples were obtained from 47 patients with various forms of primary immunodeficiency diseases (SCID, XLA, A-T, HIGM and IgAD), 20 individuals with normal serum IgA levels born to IgA-deficient mothers and 51 matched healthy newborns. Surprisingly, normal serum IgA levels were found in all SCID, XLA, A-T and HIGM patients and, additionally, in all those IgAD patients born to IgA-sufficient mothers. Conversely, no serum IgA was found in any of the 16 IgAD patients born by IgA-deficient mothers. Moreover, half of the IgA-sufficient individuals born by IgA-deficient mothers also lacked IgA at birth whereas no IgA-deficient individuals were found among the controls. IgA in neonatal dried blood samples thus appears to be of both maternal and fetal origin and precludes its use as a reliable marker for neonatal screening of primary immunodeficiency diseases.
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