SynthesisPloS one2012
Grey matter alterations co-localize with functional abnormalities in developmental dyslexia: an ALE meta-analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05832060 (Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia), which is not on this map. Cited by 106 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia
Who cites it
106 citing papers in PubMed, 6 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- The use of noninvasive brain stimulation techniques to improve reading difficulties in dyslexia: A systematic review.Human brain mapping · 2022Pooled it
- Pooled it
- Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies.Journal of neurodevelopmental disorders · 2019Pooled it
- Dyslexic brain activation abnormalities in deep and shallow orthographies: A meta-analysis of 28 functional neuroimaging studies.Human brain mapping · 2016Pooled it
- Pooled it
- Pooled it
- A functionally guided approach to the morphometry of occipitotemporal regions in developmental dyslexia: evidence for differential effects in boys and girls.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Experience-dependent cortical plasticity in response to formal schooling: Effects on networks for reading and mathematics.Developmental cognitive neuroscience · 2026Article
- Glutamatergic signaling underlies brain structural organization for mathematical and reading abilities in children.Nature communications · 2026Article
- Intergenerational transmission of the structure of the auditory cortex and reading skills.Developmental cognitive neuroscience · 2026Article
- A discovery and replication study of dyslexia does not reveal reproducible gray matter volume differences.bioRxiv : the preprint server for biology · 2026Article
- Crossroads in the Learning Brain: The Neural Overlap Between Arithmetic and Phonological Processing.Human brain mapping · 2026Article
- Cortical activations for symmetry effect on visual word form perception in developmental dyslexia.Scientific reports · 2025Article
- Neural Mechanisms Underlying Reading Impairment in Children Learning a Second Language: A Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Cognitive Training Combined with Multifocal tDCS over the Reading Network Improves Reading Performance: A Case of Severe Dyslexia.Journal of clinical medicine · 2025Article
- Exploring Memory Compensation in Dyslexia: Strengths and Weaknesses in Memory Patterns Among Children and Adolescents.Child psychiatry and human development · 2025Article
- Toward a Mechanistic Understanding of Reading Difficulties: Deviant Audiovisual Learning Dynamics and Network Connectivity in Children with Poor Reading Skills.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct impact modes of polygenic disposition to dyslexia in the adult brain.Science advances · 2024Article
- Subtitled speech: the neural mechanisms of ticker-tape synaesthesia.Brain : a journal of neurology · 2024Article
- Exploring brain plasticity in developmental dyslexia through implicit sequence learning.NPJ science of learning · 2024Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural correlates of developmental dyslexia have been investigated intensively over the last two decades and reliable evidence for a dysfunction of left-hemispheric reading systems in dyslexic readers has been found in functional neuroimaging studies. In addition, structural imaging studies using voxel-based morphometry (VBM) demonstrated grey matter reductions in dyslexics in several brain regions. To objectively assess the consistency of these findings, we performed activation likelihood estimation (ALE) meta-analysis on nine published VBM studies reporting 62 foci of grey matter reduction in dyslexic readers. We found six significant clusters of convergence in bilateral temporo-parietal and left occipito-temporal cortical regions and in the cerebellum bilaterally. To identify possible overlaps between structural and functional deviations in dyslexic readers, we conducted additional ALE meta-analyses of imaging studies reporting functional underactivations (125 foci from 24 studies) or overactivations (95 foci from 11 studies ) in dyslexics. Subsequent conjunction analyses revealed overlaps between the results of the VBM meta-analysis and the meta-analysis of functional underactivations in the fusiform and supramarginal gyri of the left hemisphere. An overlap between VBM results and the meta-analysis of functional overactivations was found in the left cerebellum. The results of our study provide evidence for consistent grey matter variations bilaterally in the dyslexic brain and substantial overlap of these structural variations with functional abnormalities in left hemispheric regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.