ArticlePloS one2012
Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 83 citations in OpenAlex.
- The Change in the Percent of Android and Gynoid Fat Mass Correlated with Increased Testosterone After Laparoscopic Sleeve Gastrectomy in Chinese Obese Men: a 6-Month Follow-Up.Obesity surgery · 2018Trial
- Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children.PloS one · 2015Trial
- Hormonal imbalance in umbilical vein cord blood of pregnant women with endometriosis: a propensity score-matched analysis.Reproductive biology and endocrinology : RB&E · 2025Article
- Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia.Current issues in molecular biology · 2024Review
- Predictive Factors of Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- A Pilot Study of Exposure to Nicotine in Human Pregnancy and Maternal and Fetal Testosterone Levels at Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Is there an association between prenatal testosterone and autistic traits in adolescents?Psychoneuroendocrinology · 2022Article
- The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up.Obesity surgery · 2021Article
- No evidence for a difference in 2D:4D ratio between youth with elevated prenatal androgen exposure due to congenital adrenal hyperplasia and controls.Hormones and behavior · 2021Article
- Incidence and Risk Factors of Hypogonadism in Male Patients With Latent Autoimmune Diabetes and Classic Type 2 Diabetes.Frontiers in endocrinology · 2021Article
- Do sex hormones at birth predict later-life economic preferences? Evidence from a pregnancy birth cohort study.Proceedings. Biological sciences · 2020Article
- SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?Clinical diabetes and endocrinology · 2020Article
- Androgen and Anti-Mullerian Hormone Concentrations at Term in Newborns and Their Mothers with and without Polycystic Ovary Syndrome.Journal of clinical medicine · 2019Article
- Predictors of Steroid Hormone Concentrations in Early Pregnancy: Results from a Multi-Center Cohort.Maternal and child health journal · 2019Article
- Sibling sex, but not androgens, shapes phenotypes in perinatal common marmosets (Callithrix jacchus).Scientific reports · 2019Article
- Maternal salivary testosterone in pregnancy and fetal neuromaturation.Developmental psychobiology · 2017Article
- Umbilical cord androgens and estrogens in relation to verbal and nonverbal abilities at age 10 in the general population.PloS one · 2017Article
- Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study.Molecular autism · 2017Article
- No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children.Journal of child psychology and psychiatry, and allied disciplines · 2016Article
- Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys with PCOS-like Traits.Current pharmaceutical design · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to measure umbilical blood androgen concentrations in a birth cohort using a highly specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay and assesses the effects of sex, labor, and gestational age on fetal androgen levels at birth. We performed a prospective cohort study of androgen concentrations in mixed arterial and venous umbilical cord serum from 803 unselected singleton pregnancies from a general obstetric population in Western Australia. Total testosterone (TT), Δ4-androstenedione, and dehydroepiandrosterone were extracted from archived cord serum samples and measured using LC-MS/MS. SHBG was measured by ELISA; free testosterone (FT) and bioavailable testosterone (BioT) values were also calculated. Median values for all three androgens were generally lower than previously published values. Levels of TT, FT, BioT, and SHBG were significantly higher in male verses female neonates (P<0.0001), while dehydroepiandrosterone levels were higher in females (P<0.0001). Labor was associated with a significant (∼15-26%) decrease in median cord blood TT and FT levels (both sexes combined), but a modest (∼16-31%) increase in SHBG, Δ4-androstenedione, and dehydroepiandrosterone concentrations. TT and FT were significantly negatively correlated with gestational age at delivery, while SHBG, Δ4-androstenedione, and dehydroepiandrosterone were positively correlated. Antenatal glucocorticoid administration also had a significant effect in the multiple regression models. This is the first study to report umbilical cord androgen levels in a large unselected population of neonates using LC-MS/MS. Our findings suggest that previous studies have over-estimated cord androgen levels, and that fetal, maternal, and obstetric factors influence cord androgen levels differentially. Caution should be exercised when interpreting previously-published data that have not taken all of these factors into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.